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Causal relationship between years of education and the occurrence of rheumatoid arthritis

Title
Causal relationship between years of education and the occurrence of rheumatoid arthritis
Author
배상철
Keywords
mendelian randomization; educational attainment; rheumatoid arthritis
Issue Date
2019-07
Publisher
BMJ PUBLISHING GROUP
Citation
POSTGRADUATE MEDICAL JOURNAL, v. 95, no. 1125, Page. 378-381
Abstract
Objective To search out whether or not years of education is causally related to rheumatoid arthritis (RA). Method We conducted a two-sample Mendelian randomisation (MR) analysis employing inverse-variance weighted (IVW), weighted median and MR-Egger regression analysis. We chose statistic data of years of education from the UK Biobank genome-wide association studies (GWASs) (n=293 723) as the exposure and a meta-analysis of GWASs of RA with autoantibody (n=5539) and European controls (n=20 169) as the outcome. Results We selected a total of 49 single nucleotide polymorphisms as instrumental variables (IVs). The IVW method instructed an inverse causative relationship between years of education and RA (beta=- 0.039, SE=0.283, p=0.008). MR-Egger regression test showed that directional pleiotropy seems not to bias the MR results (intercept=0.028; p=0.358). MR-Egger analysis demonstrated no causative relationship between RA and years of education (beta=- 2.320, SE=1.709, p=0.181). However, the weighted median approach indicated a causative association between RA and years of education (beta=-0.950, SE=0.355, p=0.008). Conclusions The MR analysis supported a potential inverse causative relationship between years of education and development of RA.
URI
https://pmj.bmj.com/content/95/1125/378https://repository.hanyang.ac.kr/handle/20.500.11754/152307
ISSN
0032-5473; 1469-0756
DOI
10.1136/postgradmedj-2018-136374
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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