Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오요한 | - |
dc.date.accessioned | 2020-07-31T02:26:32Z | - |
dc.date.available | 2020-07-31T02:26:32Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.citation | BMB REPORTS, v. 52, no. 6, Page. 349-359 | en_US |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | http://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2019.52.6.142 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/151995 | - |
dc.description.abstract | After the fist research declaring the generation of human induced pluripotent stem cells (hiPSCs) in 2007, several attempts have been made to model neurodegenerative disease in vitro during the past decade. Parkinson's disease (PD) is the second most common neurodegenerative disorder, which is mainly characterized by motor dysfunction. The formation of unique and filamentous inclusion bodies called Lewy bodies (LBs) is the hallmark of both PD and dementia with LBs. The key pathology in PD is generally considered to be the alpha-synuclein (alpha-syn) accumulation, although it is still controversial whether this protein aggregation is a cause or consequence of neurodegeneration. In the present work, the recently published researches which recapitulated the alpha-syn aggregation phenomena in sporadic and familial PD hiPSC models were reviewed. Furthermore, the advantages and potentials of using patient-derived PD hiPSC with focus on alpha-syn aggregation have been discussed. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grants funded by different governments of Korea (Ministry of Education, NRF-2017R1A6A3A03010524; Ministry of Science and ICT, NRF-2018R1C1B5045395) and by the research fund of Hanyang University (HY-2018). I sincerely apologize to colleagues whose work has not been cited in this review due to space limitations. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | en_US |
dc.subject | Aggregation | en_US |
dc.subject | Alpha-synuclein | en_US |
dc.subject | Disease modeling | en_US |
dc.subject | hiPSC | en_US |
dc.subject | Parkinson's disease | en_US |
dc.title | Patient-specific pluripotent stem cell-based Parkinson's disease models showing endogenous alpha-synuclein aggregation | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 52 | - |
dc.identifier.doi | 10.5483/BMBRep.2019.52.6.142 | - |
dc.relation.page | 349-359 | - |
dc.relation.journal | BMB REPORTS | - |
dc.contributor.googleauthor | Oh, Yohan | - |
dc.relation.code | 2019037758 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOMEDICAL SCIENCE | - |
dc.identifier.pid | yoh | - |
dc.identifier.researcherID | C-9107-2013 | - |
dc.identifier.orcid | http://orcid.org/0000-0002-9249-8664 | - |
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