Naltriben Analogues as peptide Anticancer Drugs
- Title
- Naltriben Analogues as peptide Anticancer Drugs
- Author
- 이철훈
- Keywords
- Peptide; anticancer; drug; NTB; naltriben; apoptosis
- Issue Date
- 2004-08
- Publisher
- KOREAN SOC APPLIED MICROBIOLOGY(한국미생물.생명공학회)
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 14, No. 4, Page. 881-884
- Abstract
- Apoptosis inducers for cancer therapy have beenstudied. Among hundreds of inducers, peptide anticancerdrugs have many advantages such as being not harmful tohumans, high selectivity, and dependence on their structures.Naltriben (NTB) is an octapeptide consisting of DPhe-Cys-Tyr-DTrp-Orn-Thr-Pen-Thr-NH2. Several NTB analogues areknown. In this experiment, apoptotic activities of NTB analogueswith 8 amino acids were tested using flow cytometry. Theconformational study of NTB was carried out using NMRspectroscopy and molecular modeling. Here, the relationshipsbetween conformations of NTB analogues and their apoptoticeffects are reported.
- URI
- http://kiss.kstudy.com/thesis/thesis-view.asp?key=2359949https://repository.hanyang.ac.kr/handle/20.500.11754/151630
- ISSN
- 1017-7825
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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