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Naltriben Analogues as peptide Anticancer Drugs

Title
Naltriben Analogues as peptide Anticancer Drugs
Author
이철훈
Keywords
Peptide; anticancer; drug; NTB; naltriben; apoptosis
Issue Date
2004-08
Publisher
KOREAN SOC APPLIED MICROBIOLOGY(한국미생물.생명공학회)
Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 14, No. 4, Page. 881-884
Abstract
Apoptosis inducers for cancer therapy have beenstudied. Among hundreds of inducers, peptide anticancerdrugs have many advantages such as being not harmful tohumans, high selectivity, and dependence on their structures.Naltriben (NTB) is an octapeptide consisting of DPhe-Cys-Tyr-DTrp-Orn-Thr-Pen-Thr-NH2. Several NTB analogues areknown. In this experiment, apoptotic activities of NTB analogueswith 8 amino acids were tested using flow cytometry. Theconformational study of NTB was carried out using NMRspectroscopy and molecular modeling. Here, the relationshipsbetween conformations of NTB analogues and their apoptoticeffects are reported.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2359949https://repository.hanyang.ac.kr/handle/20.500.11754/151630
ISSN
1017-7825
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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