Repository at Hanyang UniversityCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학)ETC
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dc.contributor.author이영한-
dc.date.accessioned2020-06-25T01:34:53Z-
dc.date.available2020-06-25T01:34:53Z-
dc.date.issued2004-08-
dc.identifier.citationCANCER LETTERS, v. 212, No. 2, Page. 225-231en_US
dc.identifier.urihttps://search.proquest.com/docview/1505367718?accountid=11283-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/151628-
dc.description.abstractThe Wnt signal transduction pathway plays an important role in organogenesis and carcinogenesis. In an effort to better understand the action of oxidative stress-induced cellular signaling, we investigate the effect of exogenous H2O2 on the Wnt signal pathway. H2O2 decreases the amount of nuclear b-catenin and Tcf/Lef-dependent transcription. Overexpression of Dvl-1 abrogated H2O2-induced downregulation of b-catenin. Pretreatment with LiCl or Wnt-3a conditioned medium completely inhibited H2O2-induced release of mitochondrial cytochrome c and DNA fragmentation. These results suggest that H2O2 negatively modulates the Wnt signal pathway through downregulation of b-catenin. q 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the Yeungnam University Research Grants in 2003.en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCI IRELAND LTDen_US
dc.subjectb-Cateninen_US
dc.subjectCytochrome cen_US
dc.subjectDisheveleden_US
dc.subjectDNA fragmentationen_US
dc.subjectHydrogen peroxideen_US
dc.subjectTcf/Lefen_US
dc.subjectWnt-3aen_US
dc.titleHydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-cateninen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.canlet.2004.03.003-
dc.relation.journalCANCER LETTERS-
dc.contributor.googleauthorSoon Young, Shin-
dc.contributor.googleauthorChang Gun, Kim-
dc.contributor.googleauthorMyung-Sun, Rho-
dc.contributor.googleauthorYong Sik, Kim-
dc.contributor.googleauthorYoung-Ho, Kim-
dc.contributor.googleauthorYoung Han, Lee-
dc.relation.code2009201684-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE & TECHNOLOGY[E]-
dc.sector.departmentDIVISION OF MOLECULAR & LIFE SCIENCE-
dc.identifier.pidyounghan-
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