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Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin

Title
Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin
Author
이영한
Keywords
b-Catenin; Cytochrome c; Disheveled; DNA fragmentation; Hydrogen peroxide; Tcf/Lef; Wnt-3a
Issue Date
2004-08
Publisher
ELSEVIER SCI IRELAND LTD
Citation
CANCER LETTERS, v. 212, No. 2, Page. 225-231
Abstract
The Wnt signal transduction pathway plays an important role in organogenesis and carcinogenesis. In an effort to better understand the action of oxidative stress-induced cellular signaling, we investigate the effect of exogenous H2O2 on the Wnt signal pathway. H2O2 decreases the amount of nuclear b-catenin and Tcf/Lef-dependent transcription. Overexpression of Dvl-1 abrogated H2O2-induced downregulation of b-catenin. Pretreatment with LiCl or Wnt-3a conditioned medium completely inhibited H2O2-induced release of mitochondrial cytochrome c and DNA fragmentation. These results suggest that H2O2 negatively modulates the Wnt signal pathway through downregulation of b-catenin. q 2004 Elsevier Ireland Ltd. All rights reserved.
URI
https://search.proquest.com/docview/1505367718?accountid=11283https://repository.hanyang.ac.kr/handle/20.500.11754/151628
DOI
10.1016/j.canlet.2004.03.003
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
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