Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin
- Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin
- b-Catenin; Cytochrome c; Disheveled; DNA fragmentation; Hydrogen peroxide; Tcf/Lef; Wnt-3a
- Issue Date
- ELSEVIER SCI IRELAND LTD
- CANCER LETTERS, v. 212, No. 2, Page. 225-231
- The Wnt signal transduction pathway plays an important role in organogenesis and carcinogenesis. In an effort to better
understand the action of oxidative stress-induced cellular signaling, we investigate the effect of exogenous H2O2 on the Wnt
signal pathway. H2O2 decreases the amount of nuclear b-catenin and Tcf/Lef-dependent transcription. Overexpression of Dvl-1
abrogated H2O2-induced downregulation of b-catenin. Pretreatment with LiCl or Wnt-3a conditioned medium completely
inhibited H2O2-induced release of mitochondrial cytochrome c and DNA fragmentation. These results suggest that H2O2
negatively modulates the Wnt signal pathway through downregulation of b-catenin.
q 2004 Elsevier Ireland Ltd. All rights reserved.
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- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
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