Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 장동표 | - |
dc.date.accessioned | 2020-06-16T05:32:12Z | - |
dc.date.available | 2020-06-16T05:32:12Z | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, v. 14, no. 7, Page. 5924-5937 | en_US |
dc.identifier.issn | 1452-3981 | - |
dc.identifier.uri | http://www.electrochemsci.org/abstracts/vol14/140705924.pdf | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/151609 | - |
dc.description.abstract | Both principal component regression (PCR) and partial least squares regression (PLSR) have been commonly used to predict neurochemical concentrations from measurements of fast-scan cyclic voltammetry (FSCV). However, a comparison of the accuracy of the above methods for FSCV analysis is yet to be demonstrated. In this work, we compare the concentration estimation performance of PCR and PLSR in an analysis of FSCV data. Using conventional FSCV, we recorded in vitro background-subtracted cyclic voltammograms from five neurochemicals i.e., dopamine, ascorbic acid, 3,4-dihydroxyphenylacetic acid, and serotonin, and pH change, with five concentrations of each substance and five pH values. The results showed that the absolute error (AE) and mean absolute percentage error (MAPE) were significantly smaller on average when the concentration of a single substance was predicted using PLSR compared with the use of PCR. As a further evaluation of PCR and PLSR, we compared the predictions of the concentrations of mixtures using PCR and PLSR. The AE and MAPE in the predictions obtained using PLSR were significantly smaller than those obtained using PCR. Across the single substance and the four types of mixtures, compared with PCR, PLSR showed not only higher accuracy in the prediction of concentrations but also higher selectivity. Therefore, PLSR should be preferred over PCR as a more reliable tool to analyze FSCV data. | en_US |
dc.description.sponsorship | This study was supported by an NIH 1U01NS090455-01 award and the National Research Foundation of Korea (NRF-2017R1A2B2006896). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ESG | en_US |
dc.subject | Fast-scan cyclic voltammetry (FSCV) | en_US |
dc.subject | Principal component analysis (PCR) | en_US |
dc.subject | Partial least squares regression (PLSR) | en_US |
dc.subject | Neurochemical | en_US |
dc.title | Comparison Study of Partial Least Squares Regression Analysis and Principal Component Analysis in Fast-Scan Cyclic Voltammetry | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 14 | - |
dc.identifier.doi | 10.20964/2019.07.03 | - |
dc.relation.page | 5924-5937 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE | - |
dc.contributor.googleauthor | Kim, Jaekyung | - |
dc.contributor.googleauthor | Oh, Yoonbae | - |
dc.contributor.googleauthor | Park, Cheonho | - |
dc.contributor.googleauthor | Kang, Yu Min | - |
dc.contributor.googleauthor | Shin, Hojin | - |
dc.contributor.googleauthor | Kim, In Young | - |
dc.contributor.googleauthor | Jang, Dong Pyo | - |
dc.relation.code | 2019036819 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S] | - |
dc.identifier.pid | dongpjang | - |
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