Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이지영 | - |
dc.date.accessioned | 2020-06-08T01:48:17Z | - |
dc.date.available | 2020-06-08T01:48:17Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | NEURORADIOLOGY, v. 61, no. 3, Page. 265-274 | en_US |
dc.identifier.issn | 0028-3940 | - |
dc.identifier.issn | 1432-1920 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00234-018-2130-1 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/151499 | - |
dc.description.abstract | PurposeWhite matter hyperintensities (WMH) and cerebral microbleeds (CMBs) are known to be associated with small vessel diseases (SVD) and neuroinflammation. The purpose was to investigate the relationship between CMBs and WMH in patients with systemic lupus erythematosus (SLE).MethodsThirty-one SLE patients with WMH and 27 SLE patients with normal brain MRI were compared. The presence, location, and grading of CMBs were assessed using susceptibility-weighted images. WMH volume was quantitatively measured. Clinical characteristics and serologic markers were compared. We also performed two separate subgroup analyses after (1) dividing WMH into inflammatory lesion vs. SVD subgroups and (2) dividing WMH into those with vs. without CMB subgroups.ResultsThe WMH group showed more frequent CMBs than the normal MR group (p<0.001). The WMH group showed higher SLE disease activity index, longer disease duration, and a higher incidence of antiphospholipid syndrome than the normal MR group (p=0.02, 0.04, and 0.04, respectively). There was a moderate correlation between WMH volume and CMB grading (r=0.49, p=0.006). Within the WMH group, the inflammatory lesion subgroup showed more frequent CMBs and larger WMH volume than the SVD subgroup (p<0.001 and 0.02, respectively). The WMH with CMB subgroup had larger WMH volume than the WMH without CMB subgroup (p=0.004).ConclusionIn patients with SLE, CMBs could be related to large-volume WMH and inflammatory lesions. CMBs along with severe WMH could be used as an imaging biomarker of vasculitis in patients with SLE. | en_US |
dc.description.sponsorship | This study was funded by a grant from the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant no. HI09C1379 [A092077]). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | Systemic lupus erythematosus | en_US |
dc.subject | White matter | en_US |
dc.subject | Cerebral microbleeds | en_US |
dc.subject | Magnetic resonance imaging | en_US |
dc.subject | Susceptibility weighted imaging | en_US |
dc.title | Relationship between cerebral microbleeds and white matter MR hyperintensities in systemic lupus erythematosus: a retrospective observational study. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1007/s00234-018-2130-1 | - |
dc.relation.journal | NEURORADIOLOGY | - |
dc.contributor.googleauthor | Yeoh, Hyunjung | - |
dc.contributor.googleauthor | Lee, Ji Young | - |
dc.contributor.googleauthor | Lee, Young-Jun | - |
dc.contributor.googleauthor | Park, Dong Woo | - |
dc.contributor.googleauthor | Kim, Tae Yoon | - |
dc.contributor.googleauthor | Ahn, Ga Young | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Kim, Young Seo | - |
dc.contributor.googleauthor | Kim, Hyun Young | - |
dc.contributor.googleauthor | Kim, Chun K. | - |
dc.relation.code | 2019000627 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | mdjylee | - |
dc.identifier.orcid | https://orcid.org/0000-0003-1181-8070 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.