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dc.contributor.author이지영-
dc.date.accessioned2020-06-08T01:48:17Z-
dc.date.available2020-06-08T01:48:17Z-
dc.date.issued2019-03-
dc.identifier.citationNEURORADIOLOGY, v. 61, no. 3, Page. 265-274en_US
dc.identifier.issn0028-3940-
dc.identifier.issn1432-1920-
dc.identifier.urihttps://link.springer.com/article/10.1007/s00234-018-2130-1-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/151499-
dc.description.abstractPurposeWhite matter hyperintensities (WMH) and cerebral microbleeds (CMBs) are known to be associated with small vessel diseases (SVD) and neuroinflammation. The purpose was to investigate the relationship between CMBs and WMH in patients with systemic lupus erythematosus (SLE).MethodsThirty-one SLE patients with WMH and 27 SLE patients with normal brain MRI were compared. The presence, location, and grading of CMBs were assessed using susceptibility-weighted images. WMH volume was quantitatively measured. Clinical characteristics and serologic markers were compared. We also performed two separate subgroup analyses after (1) dividing WMH into inflammatory lesion vs. SVD subgroups and (2) dividing WMH into those with vs. without CMB subgroups.ResultsThe WMH group showed more frequent CMBs than the normal MR group (p<0.001). The WMH group showed higher SLE disease activity index, longer disease duration, and a higher incidence of antiphospholipid syndrome than the normal MR group (p=0.02, 0.04, and 0.04, respectively). There was a moderate correlation between WMH volume and CMB grading (r=0.49, p=0.006). Within the WMH group, the inflammatory lesion subgroup showed more frequent CMBs and larger WMH volume than the SVD subgroup (p<0.001 and 0.02, respectively). The WMH with CMB subgroup had larger WMH volume than the WMH without CMB subgroup (p=0.004).ConclusionIn patients with SLE, CMBs could be related to large-volume WMH and inflammatory lesions. CMBs along with severe WMH could be used as an imaging biomarker of vasculitis in patients with SLE.en_US
dc.description.sponsorshipThis study was funded by a grant from the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant no. HI09C1379 [A092077]).en_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.subjectSystemic lupus erythematosusen_US
dc.subjectWhite matteren_US
dc.subjectCerebral microbleedsen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectSusceptibility weighted imagingen_US
dc.titleRelationship between cerebral microbleeds and white matter MR hyperintensities in systemic lupus erythematosus: a retrospective observational study.en_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00234-018-2130-1-
dc.relation.journalNEURORADIOLOGY-
dc.contributor.googleauthorYeoh, Hyunjung-
dc.contributor.googleauthorLee, Ji Young-
dc.contributor.googleauthorLee, Young-Jun-
dc.contributor.googleauthorPark, Dong Woo-
dc.contributor.googleauthorKim, Tae Yoon-
dc.contributor.googleauthorAhn, Ga Young-
dc.contributor.googleauthorBae, Sang-Cheol-
dc.contributor.googleauthorKim, Young Seo-
dc.contributor.googleauthorKim, Hyun Young-
dc.contributor.googleauthorKim, Chun K.-
dc.relation.code2019000627-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidmdjylee-
dc.identifier.orcidhttps://orcid.org/0000-0003-1181-8070-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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