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dc.contributor.author한명훈-
dc.date.accessioned2020-06-05T02:23:48Z-
dc.date.available2020-06-05T02:23:48Z-
dc.date.issued2019-06-
dc.identifier.citationPLOS ONE, v. 14, no. 6, article no. e0218825en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218825-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/151470-
dc.description.abstractBackground and purpose Low body mass index (BMI) at presentation has been reported to be associated with higher incidence and mortality of lung cancer, but studies on the relationship between brain metastasis and BMI at presentation are lacking. This study aimed to evaluate the association between brain metastasis and BMI and bone mineral density (BMD) in NSCLC. Methods We retrospectively enrolled patients with non-small cell lung cancer who underwent brain magnetic resonance imaging with contrast within 3 months of diagnosis. The BMI was collected, and the BMD was measured in Hounsfield unit (HU) on initial staging computed tomography scans. The independent relationship between BMI and BMD was assessed using multivariable linear regression according to the presence of brain metastasis. Results A total of 356 consecutive NSCLC patients were enrolled in the study over a 8-year period in a single institution. Lower BMI with higher BMD was an independent predictive factor for brain metastasis in patients with NSCLC, relative to the other group (HR, 2.03; 95% CI, 1.21 to 3.40; P = 0.007). We also found a significant negative correlation between BMI and BMD among patients with NSCLC with brain metastases (B, -3.343; 95% confidence interval, -6.352 to -0.333; P = 0.030). Conclusions Brain metastasis may possibly be associated with lower BMI and higher BMD in NSCLC patients. We expect that these results may facilitate future predictions of brain metastases during the clinical course of NSCLC and enhance our understanding of the underlying mechanisms that link brain metastases and lung cancer.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-201800000002600), http://www.hanyang.ac.kr/web/eng, to HMH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This work was supported by the research fund of Hanyang University (HY-201800000002600).en_US
dc.language.isoenen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.subjectBETA-CATENINen_US
dc.subjectBREAST-CANCERen_US
dc.subjectOSTEOBLASTOGENESISen_US
dc.subjectOBESITYen_US
dc.subjectINTERLEUKIN-6en_US
dc.subjectADIPOGENESISen_US
dc.subjectOVERWEIGHTen_US
dc.titleParadoxical relationship between body mass index and bone mineral density in patients with non–small cell lung cancer with brain metastasisen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0218825-
dc.relation.page0-0-
dc.relation.journalPLOS ONE-
dc.contributor.googleauthorNam, Min Woo-
dc.contributor.googleauthorKim, Jae Min-
dc.contributor.googleauthorCheong, Jin Hwan-
dc.contributor.googleauthorRyu, Je Il-
dc.contributor.googleauthorHan, Myung-Hoon-
dc.relation.code2019042142-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidgksmh80-
dc.identifier.orcidhttps://orcid.org/0000-0003-1728-5017-


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