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dc.contributor.author노민영-
dc.date.accessioned2020-06-04T05:51:41Z-
dc.date.available2020-06-04T05:51:41Z-
dc.date.issued2019-06-
dc.identifier.citationDEMENTIA AND NEUROCOGNITIVE DISORDERS, Page. 33-46en_US
dc.identifier.issn1738-1495-
dc.identifier.issn2384-0757-
dc.identifier.urihttps://dnd.or.kr/DOIx.php?id=10.12779/dnd.2019.18.2.33-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/151448-
dc.description.abstractAlzheimer's disease (AD), the most common form of dementia, has emerged as a major global public health challenge. However, the complexity of AD in its biological, genetic, and clinical aspects has hindered the development of effective therapeutic agents. Research plans that integrate new drug discoveries are urgently needed, including those based on novel and reliable biomarkers that reflect not only clinical phenotype, but also genetic and neuroimaging information. Therapeutic strategies such as stratification (i.e., subgrouping of patients having similar clinical characteristics or genetic background) and personalized medicine could be set as new directions for developing effective drugs for AD. In this review, we describe a therapeutic strategy that is based on immune-inflammation modulation for a subgroup of AD and related dementias, arguing that the use of stratification and personalized medicine is a promising way to achieve targeted medicine. The Korean AD Research Platform Initiative based on Immune-Inflammatory biomarkers (K-ARPI) has recently launched a strategy to develop novel biomarkers to identify a subpopulation of patients with AD and to develop new drug candidates for delaying the progression of AD by modulating toxic immune inflammatory response. Sphingosine kinase 1 (SphK1) and its metabolites, triggering receptor expressed on myeloid cells-2 (TREM2) related signals, and actin motility related proteins including Nck-associated protein 1 (Nap1) were selected as promising targets to modulate neuroinflammation. Their roles in stratification and personalized medicine will be discussed.en_US
dc.description.sponsorshipThis study was supported by the National Research Foundation (NRF) of Korea funded by the Korea Ministry of Science (2018M3C7A1056512), And also supported by the Korea Health Technology R&D Project through the Korea Health Industry, Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI16C2131).en_US
dc.language.isoenen_US
dc.publisher대한치매학회en_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectInflammationen_US
dc.subjectPersonalized Medicineen_US
dc.subjectBiomarkersen_US
dc.titleA Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation.en_US
dc.typeArticleen_US
dc.identifier.doi10.12779/dnd.2019.18.2.33-
dc.relation.page33-46-
dc.relation.journalDEMENTIA AND NEUROCOGNITIVE DISORDERS-
dc.contributor.googleauthorKim, Seung Hyun-
dc.contributor.googleauthorNoh, Min Young-
dc.contributor.googleauthorKim, Hee-Jin-
dc.contributor.googleauthorOh, Ki-Wook-
dc.contributor.googleauthorPark, Jinseok-
dc.contributor.googleauthorLee, Sanggon-
dc.contributor.googleauthorMoon, Yeonsil-
dc.contributor.googleauthorKim, Young-Eun-
dc.contributor.googleauthorBae, Jae-sung-
dc.contributor.googleauthorJin, Hee Kyung-
dc.relation.code2012215947-
dc.sector.campusS-
dc.sector.daehakRESEARCH INSTITUTE[S]-
dc.sector.departmentINSTITUTE FOR THE INTERGRATION OF MEDICINE AND INNOVATIVE TECHNOLOGY-
dc.identifier.pidnmy-


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