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A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation.

Title
A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation.
Author
노민영
Keywords
Alzheimer's Disease; Inflammation; Personalized Medicine; Biomarkers
Issue Date
2019-06
Publisher
대한치매학회
Citation
DEMENTIA AND NEUROCOGNITIVE DISORDERS, Page. 33-46
Abstract
Alzheimer's disease (AD), the most common form of dementia, has emerged as a major global public health challenge. However, the complexity of AD in its biological, genetic, and clinical aspects has hindered the development of effective therapeutic agents. Research plans that integrate new drug discoveries are urgently needed, including those based on novel and reliable biomarkers that reflect not only clinical phenotype, but also genetic and neuroimaging information. Therapeutic strategies such as stratification (i.e., subgrouping of patients having similar clinical characteristics or genetic background) and personalized medicine could be set as new directions for developing effective drugs for AD. In this review, we describe a therapeutic strategy that is based on immune-inflammation modulation for a subgroup of AD and related dementias, arguing that the use of stratification and personalized medicine is a promising way to achieve targeted medicine. The Korean AD Research Platform Initiative based on Immune-Inflammatory biomarkers (K-ARPI) has recently launched a strategy to develop novel biomarkers to identify a subpopulation of patients with AD and to develop new drug candidates for delaying the progression of AD by modulating toxic immune inflammatory response. Sphingosine kinase 1 (SphK1) and its metabolites, triggering receptor expressed on myeloid cells-2 (TREM2) related signals, and actin motility related proteins including Nck-associated protein 1 (Nap1) were selected as promising targets to modulate neuroinflammation. Their roles in stratification and personalized medicine will be discussed.
URI
https://dnd.or.kr/DOIx.php?id=10.12779/dnd.2019.18.2.33https://repository.hanyang.ac.kr/handle/20.500.11754/151448
ISSN
1738-1495; 2384-0757
DOI
10.12779/dnd.2019.18.2.33
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > ETC
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