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dc.contributor.author오기욱-
dc.date.accessioned2020-04-17T06:26:39Z-
dc.date.available2020-04-17T06:26:39Z-
dc.date.issued2019-04-
dc.identifier.citationJOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 90, NO 4, Page. 395-403en_US
dc.identifier.issn0022-3050-
dc.identifier.issn1468-330X-
dc.identifier.urihttps://jnnp.bmj.com/content/90/4/395-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/151101-
dc.description.abstractObjective This study aimed to determine the incidence, prevalence and survival time of Korean patients with amyotrophic lateral sclerosis (ALS) using National Health Insurance Service (NHIS) data. Methods Using NHIS data, the Korean nationwide health dataset, we identified patients with motor neuron diseases who were first diagnosed with a KCD-6 code (G12.20-G12.28; modified from ICD-10 codes) between 2011 and 2015. ALS (G12.21 code) epidemiological characteristics, including annual incidence, prevalence, mortality rates and survival time, were analysed and compared with sociodemographic variables. Results New patients with ALS (n= 3049) were enrolled over 5 years. The mean annual incidence was 1.20/100 000, and the sex ratio was 1.60 (male: female). The mean age at the time of diagnosis was 61.4 years. The prevalence rate was 3.43/100 000 in 2015. In this period, riluzole was prescribed to 53.6% of patients with ALS. Furthermore, 20.3% of patients with ALS underwent tracheostomy. When analysed for age and socioeconomic status, ALS prevalence rate was 10.71 in the aged group (>= 60) in 2015 and was lowest in the middle-income group compared with that in the high-income and low-income groups. The estimated mean survival time in this population was 50.0 months, and the 3-year and 5-year mortality rates were 52.1% and 63.7%, respectively. Conclusions This study is the first nationwide survey for epidemiological characteristics of ALS in Korea using national data. The use of these data substantially advances the understanding of Korean and Asian ALS epidemiology and its relationship with socioeconomic status, age and sex.en_US
dc.description.sponsorshipBrain Research Program through the National Research Foundation of Korea (NRF), Korean Health Technology R&D Project, Ministry of Health, Welfare and Family Affairs, Republic of Korea.en_US
dc.language.isoenen_US
dc.publisherBMJ PUBLISHING GROUPen_US
dc.subjectAMYOTROPHIC-LATERAL-SCLEROSISen_US
dc.subjectMOTOR-NEURON DISEASEen_US
dc.subjectDIAGNOSISen_US
dc.subjectSURVIVALen_US
dc.subjectPREVALENCEen_US
dc.subjectMANAGEMENTen_US
dc.subjectIRELANDen_US
dc.subjectTRIALen_US
dc.subjectCAREen_US
dc.titleEpidemiology of ALS in Korea using nationwide big dataen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume90-
dc.identifier.doi10.1136/jnnp-2018-318974-
dc.relation.page395-403-
dc.relation.journalJOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY-
dc.contributor.googleauthorJun, Kyo Yeon-
dc.contributor.googleauthorPark, Jinseok-
dc.contributor.googleauthorOh, Ki-Wook-
dc.contributor.googleauthorKim, Eun Mi-
dc.contributor.googleauthorBae, Jong Seok-
dc.contributor.googleauthorKim, Inah-
dc.contributor.googleauthorKim, Seung Hyun-
dc.relation.code2019002960-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkiwook-oh-


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