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Cell Cycle Arrest and Apoptotic Induction by MCS-C2 in Human Leukemia HL-60 Cells

Title
Cell Cycle Arrest and Apoptotic Induction by MCS-C2 in Human Leukemia HL-60 Cells
Author
이철훈
Issue Date
2004-06
Publisher
The Korean Society for Microbiology and Biotechnology
Citation
Proceedings of the Korean Society for Applied Microbiology Conference, Page. 297-301
Abstract
The purpose of the present study was to investigate the anti-proliferative and apoptotic effects of MCS-C2, a novel analogue of toyocamycin and sangivamycin, in human promyelocytic leukemia (HL-60) cells. When treated with MCS-C2, inhibited proliferation associated with cell cycle arrest and apoptotic induction was found in the HL-60 cells in a concentration-dependent and time-dependent manner. This apoptotic induction was associated with the cleavage of Bid and a release of cytochrome c from mitochondria into the cytosol, followed by the activation of caspase-3 and inactivation of poly (ADP-ribose) polymerase (PARP). However, there was no significant change in any other mitochondrial membrane proteins, such as Bcl-2 and Bax. Consequently, the current findings suggest that the mitochondrial pathway was primarily involved in the MCS-C2-induced apoptosis in the human promyelocytic leukemia HL-60 cells.
URI
http://www.koreascience.or.kr/article/CFKO200411923007760.pagehttps://repository.hanyang.ac.kr/handle/20.500.11754/149394
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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