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Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAgue Determined by Computed TomoGraphic Angiography Imaging) substudy

Title
Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAgue Determined by Computed TomoGraphic Angiography Imaging) substudy
Author
허란
Keywords
Pre-diabetes; Coronary atherosclerosis; Coronary computed tomography angiography
Issue Date
2019-03
Publisher
ELSEVIER SCIENCE INC
Citation
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, v. 13, NO 2, Page. 142-147
Abstract
Background: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA). Methods: A total of 1296 subjects (61 +/- 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). Results: During the follow-up, significant differences in PVC (normal: 51.3 +/- 83.3 mm(3) vs. pre-DM: 51.0 +/- 84.3 mm(3) vs. DM: 72.6 +/- 95.0 mm(3); p < 0.001) and annualized PVC (normal: 14.9 +/- 24.9 mm(3) vs. pre-DM: 15.7 +/- 23.8 mm(3) vs. DM: 21.0 +/- 27.7 mm(3); p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967-1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126-2.375; p = 0.010). Conclusion: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors.
URI
https://www.sciencedirect.com/science/article/pii/S1934592518301813?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/149348
ISSN
1934-5925
DOI
10.1016/j.jcct.2018.12.002
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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