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PPAR gamma ligands sensitize non-small cell lung cancer cells(NSCLC) to ionizing radiation-induced apoptosis

Title
PPAR gamma ligands sensitize non-small cell lung cancer cells(NSCLC) to ionizing radiation-induced apoptosis; the role of ROS-induced DNA damage

Title
the role of ROS-induced DNA damage
Other Titles
PPAR gammaligands가 유발하는 ROS에 의한 DNA damage를 통한 방사선 apoptosis증진 효과
Author
박선화
Advisor(s)
신인철,홍성희
Issue Date
2011-02
Publisher
한양대학교
Degree
Master
Abstract
We investigated possible radio-sensitizing possible radio-sensitizing acticities of a well known PPAR gamma ligand ciglitazone and novel PPAR gamma ligands CAY10415 and CAY10506 in human non-small lung cancer cells. These three PPAR gamma ligands enhanced ionizing radiation (IR)-induced apoptosis and caspase-3-mediated PARP cleavage. The combined PPAR gamma ligands-IR treatment also triggered caspase-8 activation and this initiator caspase exerted a critical role in the combination-induced apoptosis. In addition, PPAR gamma ligands could also enhanced IR-induced DNA damage response such as ��H2AX. Moreover, the combination treatment significantly increased ROS generation, and ROS scavengers such as NAC, but not Tiron, inhibited the combined treatment-induced ROS generation and apoptotic cell death. Taken together, these results indicate that the combined treatment of PPAR gamma ligands and IR synergistically induced DNA damage and apoptosis, and ROS are critical regulators of these enhanced DNA damage and apoptosis
URI
https://repository.hanyang.ac.kr/handle/20.500.11754/140023http://hanyang.dcollection.net/common/orgView/200000415895
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > LIFE SCIENCE(생명과학과) > Theses (Master)
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