All the loads in the real world are dynamic loads and it is well known that structural optimization under dynamic loads is very difficult. Thus the dynamic loads are often transformed to the static loads using dynamic factors. However, due to the difference of load characters, there can be considerable differences between the results from static and dynamic analyses. When the natural frequency of a structure is high, the dynamic analysis result is similar to that of static analysis due to the small inertia effect on the behavior of the structure. However, if the natural frequency is low, the inertia effect should not be ignored. Then, the behavior of the dynamic system is different from that of the static system. The difference of the two cases can be explained from the relationship between the homogeneous and the particular solutions of the differential equation that governs the behavior of the structure. Through various examples, the difference between the dynamic analysis and the static analysis are shown. Also the optimization results considering dynamic loads are compared with static loads.