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Hierarchical Nanostructures of Organic-Inorganic Hybrid Materials for Surface Enhanced Raman Scattering-based Bioimaging and Smart Drug Delivery

Title
Hierarchical Nanostructures of Organic-Inorganic Hybrid Materials for Surface Enhanced Raman Scattering-based Bioimaging and Smart Drug Delivery
Author
굴람자라니
Advisor(s)
Dong Woo Lim
Issue Date
2012-02
Publisher
한양대학교
Degree
Master
Abstract
Biohybrid nanoarchitectures of organic-inorganic nanocomposites possess fascinating chemical, physical and optical properties for a variety of applications ranging from biomedical engineering, environmental sciences to chemical and materials engineering. Plasmonic nanoarchitectures of nobel metals like silver and gold in combination with biocompatible polymeric hydrogels act as sensitive optical probes and substrates to be used for biomedical imaging and chemical sensing applications. Surface Enhanced Raman Scattering (SERS) has evolved to be an excellent example of ultra-sensitive photo analytical technique down to single molecular level. SERS based bioimaging is a powerful, nondestructive and nontoxic analytical practice for the detection and cellular imaging of live cells and tissues. Highly desirable characteristics are coupled with SERS based bioimaging like excellent multiplexing ability with minimal background signal and negligible photodecay of the signal. In this report we have developed highly sensitive biohybrid SERS active nanoprobes and substrates for specific bioimaging of cancer cells and chemical trace analysis. The other class of smart nanocomposites composed of stimuli responsive polymers have been investigated for promising applications in multimodal drug delivery and tissue engineering.
URI
http://dcollection.hanyang.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000062907https://repository.hanyang.ac.kr/handle/20.500.11754/137329
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Theses (Master)
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