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목초액의 혈소판 응집억제를 통한 혈행개선 작용에 관한 연구

Title
목초액의 혈소판 응집억제를 통한 혈행개선 작용에 관한 연구
Other Titles
Improvement of Haemostasis Mediated by Anti-Platelet Activities by Plant Vinegar
Author
배옥남
Keywords
Plant vinegar; Platelets; Cytotoxicity; Antiplatelet activity; Cardiovascular disease
Issue Date
2004-03
Publisher
한국독성학회
Citation
Journal of Toxicology and Public Health, v. 20, No. 1, Page. 137-142
Abstract
We investigated the effects of plant vinegar on platelets and blood coagulation system. Plant vinegar inhibited in vitro platelet aggregation in a concentration dependent manner, when platelets were activated by thrombin and collagen. In addition, plant vinegar showed inhibitory effects on the serotonin secretion induced by thrombin in a concentration dependent manner. However, treatment with plant vinegar to platelets did not induce any cytotoxicity, as determined by the release of lactate dehydrogenase. Plant vinegar did not change the coagulation parameters such as activated partial thromboplastin time (aPTT) and prothrombin time (PT) using rat citrated plasma. In vivo study revealed that, treatment with plant vinegar prolonged the bleeding time from mouse tail. All these results suggest that plant vinegar might improve blood hemostasis mediated via antiplatelet activities.
URI
http://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE00544171&language=ko_KRhttps://repository.hanyang.ac.kr/handle/20.500.11754/136800
ISSN
1976-8257; 2234-2753
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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