국부온열치료용 자성나노입자와 나노복합재료의 합성 및 특성평가

Abstract

cancer killing by heating. These days, hyperthermia together with chemotherapy shows improved cancer treatment effects. So, we successfully synthesized magnetite nanoparticles by thermal decomposition method. This research focused on the synthesis of magnetite nanoparticles by thermal decomposition and the dispersion of the particles within nanoporous aerogel matrices for the application of hyperthermia and chemotherapy. We could present the possibilities of the dispersion of magnetite nanoparticles within aerogels by infiltrating magnetite precursor solution and forming nanoparticles, and infilitrating magnetite nanoparticles synthesized previously into aerogels. 20-30% of nanoparticles (NPs) could be dispersed within aerogels and showed hyperthermia effects; 45oC of temperature increased when 560 Oe of magnetic field was applied. Further, We also tried to disperse the NPs into the mesoporous silica using the CTAB (cethyltrimethylammonium bromide) and PEG (Poly ethylene glycol) coating. The dispersion of magnetite NPs into aerogel matrices, mesoporous silica and PEG coating give two merits: the homogeneous dispersion of the NPs and the hyperthermia effects of the NPs under alternating magnetic field, and the drug delivery by nanoporous matrices. The hyperthermal effects of the NPs within aerogels were also characterized.; Magnetite nanocrystals draw many attractions of their applications for hyperthermia therapy