Phage display를 통한 유방암 줄기세포 특이 표식인자 CD44에 결합하는 펩타이드의 선별 및 특성화 규명.
- Title
- Phage display를 통한 유방암 줄기세포 특이 표식인자 CD44에 결합하는 펩타이드의 선별 및 특성화 규명.
- Other Titles
- Screening and characterization of peptides binding on breast cancer stem cell biomarker CD44 by phage display.
- Author
- 이경진
- Alternative Author(s)
- Lee, Kyoung Jin
- Advisor(s)
- 윤문영
- Issue Date
- 2013-02
- Publisher
- 한양대학교
- Degree
- Master
- Abstract
- CD44, a cancer-associated membrane glycoprotein involved in cell adhesion and tumor progression, has been implicated as a cancer stem cell antigen in several cancers including breast cancer. If the detection sensitivity of CD44 as an early marker for cancer could be improved, this would have important clinical applications. As compared with early stage treatments of other kinds of cancer, treatment of breast cancer is more likely to results in positive outcomes, so this early detection is crucial. Therefore, CD44 is a potential diagnostic target for cancer detection. Herein, we have used a peptide library to screen novel diverse peptides that bind to CD44 with high affinity and characterized the specific binding of these peptides. Our work provides a basis to develop novel diagnostic peptides which may replace antibodies as CD44 detection probes.
- URI
- https://repository.hanyang.ac.kr/handle/20.500.11754/133620http://hanyang.dcollection.net/common/orgView/200000420964
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > CHEMISTRY(화학과) > Theses (Master)
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