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유방암 아형에 따른 FDG 섭취 정도 차이 분석

Title
유방암 아형에 따른 FDG 섭취 정도 차이 분석
Other Titles
18F-FDG Uptake in Breast Cancer Correlates with Immunohistochemically-Defined Subtypes
Author
구혜령
Alternative Author(s)
Hye Ryoung Koo
Advisor(s)
박정선
Issue Date
2014-02
Publisher
한양대학교
Degree
Doctor
Abstract
The aim of this study was to determine whether a correlation exists between SUVmax on FDG-PET and the subtypes of breast cancer. This retrospective study involved 548 patients (mean age: 51.6 years
range: 21–81 years) with 552 index breast cancers (mean size: 2.57cm
range: 1.0–14.5 cm). The correlation between 18F-FDG uptake in PET/CT, expressed as maximum standardized uptake value (SUVmax), and immunohistochemically-defined subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 (HER2)-positive, and triple-negative) was analyzed. The mean SUVmax value of the 552 tumors was 6.07 ± 4.63 (range: 0.9–32.8). The subtypes of the 552 tumors were 334 (60%) luminal A
66 (12%) luminal B
60 (11%) HER2-positive
and 92 (17%) triple-negative
for which the mean SUVmax values were 4.69 ± 3.45
6.51 ±4.18
7.44 ± 4.73
and 9.83 ± 6.03, respectively. In a multivariate regression analysis, triple-negative and HER2-positive tumors had 1.67-fold (P< 0.001) and 1.27-fold (P = 0.009) higher SUVmax values, respectively, than luminal A tumors after adjustment for invasive tumor size, lymph node involvement status, and histologic grade. FDG uptake was independently associated with subtypes of invasive breast cancer. Triple-negative and HER2-positive breast cancers showed higher SUVmax values than did luminal A tumors.
URI
https://repository.hanyang.ac.kr/handle/20.500.11754/131363http://hanyang.dcollection.net/common/orgView/200000424051
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > MEDICINE(의학과) > Theses (Ph.D.)
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