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CD24의 p38MAPK와 Notch1 mRNA 안정성을 통한 EMT와 암줄기세포 유지능력 조절

Title
CD24의 p38MAPK와 Notch1 mRNA 안정성을 통한 EMT와 암줄기세포 유지능력 조절
Other Titles
CD24 regulates stemness and the epithelial to mesenchymal transition through modulation of Notch1 mRNA stability by p38MAPK
Author
임주연
Alternative Author(s)
Lim, Ju Yeon
Advisor(s)
신인철
Issue Date
2014-02
Publisher
한양대학교
Degree
Master
Abstract
I report here that CD24 knockdown resulted in decreased expression of Notch1 in MCF-7 cells. CD24-downstream p38MAPK was shown to regulate Notch1 at the level of mRNA stability. I also found that CD24-mediated cell migration, invasion, mammosphere formation, and drug resistance was regulated by its downstream target Notch1. Together, our results indicate that CD24 may regulate the epithelial to mesenchymal transition and stemness through Notch1 signaling in breast cancer cells.
URI
https://repository.hanyang.ac.kr/handle/20.500.11754/131154http://hanyang.dcollection.net/common/orgView/200000423237
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > LIFE SCIENCE(생명과학과) > Theses (Master)
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