마이크로플루딕스 기술을 이용한 인지질 고분자 하이드로젤 구조체의 제조 및 투과거동에 대한 연구

Abstract

CHAPTER1. Microfluidic Fabrication and Permeation Behaviors of Uniform Zwitterionic Hydrogel Microparticles and Shells

This study introduces a flexible and straightforward method for generating monodisperse suspensions of hydrogel microparticles. For this, a water-in-oil emulsion was generated in a microcapillary device and then the emulsion drops were photo-polymerized to transfer them to hydrogel particles. The hydrogel microparticles were made of poly(2-methacryloyloxyethyl phosphorylcholine) that has an enhanced biocompatibility due to the phosphoryl choline moiety in the backbone. The average mesh size of the hydrogel network, which is ~50 Å, was estimated on the basis of the Peppas-Merrill equation. This mesh size was experimentally confirmed by carrying out a permeation test for the dextran macromolecules having different molecular weights. Furthermore, to diversify the applicability of microfluidic technology, an oil-in-water-in-oil double emulsion was also fabricated by using the co-axial jetting of three combined flows in the micro-channel. Then the aqueous shell was polymerized to give rise to hollow-structured hydrogel microparticles. Finally, we have shown that the microfluidic approach is useful for fabrication of complex hydrogel microparticles that have potential uses in drug immobilization and delivery.|CHAPTER2. Immobilization of Polymeric Micelles in Uniform Hydrogel Microparticles Produced in Microfluidic Device

This study introduces a flexible and straightforward method for immobilization of polymeric micelles in monodisperse suspensions of hydrogel microparticles. Hydrogel particles loaded with poly(glycerol)-b-poly(ε-caprolactone) micelles were prepared using a microfluidic method. For this, a uniform water-in-oil emulsion was generated in a microcapillary device and then the emulsion drops including polymeric micelles in water part were photo-polymerized to transform them to hydrogel particles. The hydrogel phase was made of poly(2-methacryloyloxyethyl phosphorylcholine), poly (MPC) that has an enhanced biocompatibility due to the phosphoryl choline moiety in the backbone. Finally, we have demonstrated that the microfluidic approach is useful for physically immobilizing polymeric micelles in between poly (MPC) meshes, which enables more controlled release of active ingredients encapsulated in the micelle.; CHAPTER2. Immobilization of Polymeric Micelles in Uniform Hydrogel Microparticles Produced in Microfluidic Device

This study introduces a flexible and straightforward method for immobilization of polymeric micelles in monodisperse suspensions of hydrogel microparticles. Hydrogel particles loaded with poly(glycerol)-b-poly(ε-caprolactone) micelles were prepared using a microfluidic method. For this, a uniform water-in-oil emulsion was generated in a microcapillary device and then the emulsion drops including polymeric micelles in water part were photo-polymerized to transform them to hydrogel particles. The hydrogel phase was made of poly(2-methacryloyloxyethyl phosphorylcholine), poly (MPC) that has an enhanced biocompatibility due to the phosphoryl choline moiety in the backbone. Finally, we have demonstrated that the microfluidic approach is useful for physically immobilizing polymeric micelles in between poly (MPC) meshes, which enables more controlled release of active ingredients encapsulated in the micelle.