화학적 개조를 통한 Graphene Oxide의 광학적 특성 조율 및 신경전달물질 검출을 위한 응용 연구

Abstract

Designing artificial nanomaterials capable of selectively detecting targets without the use of expensive and fragile antibodies is of great interest in the applications of nanomedicine. Here, I show that the fluorescence of graphene oxide (GO) was chemically modulated for the selective detection of a neurotransmitter without the use of antibodies. GO was functionalized with nitrotriacetic acid (NTA) on which four different metal ions were chelated (M-NTA-GO), which led to its different fluorescence responses to neurotransmitters. In particular, the Cu-NTA-GO hybrid was able to selectively detect norepinephrine at nanomolar concentrations by its “turn-on” fluorescence. Moreover, it was successfully applied to the selective detection of norepinephrine secreted from living PC-12 cells.