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화학적 개조를 통한 Graphene Oxide의 광학적 특성 조율 및 신경전달물질 검출을 위한 응용 연구

Title
화학적 개조를 통한 Graphene Oxide의 광학적 특성 조율 및 신경전달물질 검출을 위한 응용 연구
Other Titles
Chemical Modulation of Optical Properties of Graphene Oxide and Its Application to Neurotransmitter Detection
Author
전수지
Alternative Author(s)
Jeon, Su-Ji
Advisor(s)
김종호
Issue Date
2014-08
Publisher
한양대학교
Degree
Master
Abstract
Designing artificial nanomaterials capable of selectively detecting targets without the use of expensive and fragile antibodies is of great interest in the applications of nanomedicine. Here, I show that the fluorescence of graphene oxide (GO) was chemically modulated for the selective detection of a neurotransmitter without the use of antibodies. GO was functionalized with nitrotriacetic acid (NTA) on which four different metal ions were chelated (M-NTA-GO), which led to its different fluorescence responses to neurotransmitters. In particular, the Cu-NTA-GO hybrid was able to selectively detect norepinephrine at nanomolar concentrations by its “turn-on” fluorescence. Moreover, it was successfully applied to the selective detection of norepinephrine secreted from living PC-12 cells.
URI
http://dcollection.hanyang.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000079853https://repository.hanyang.ac.kr/handle/20.500.11754/130335
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > FUSION CHEMICAL ENGINEERING(융합화학공학과) > Theses (Master)
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