Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 최한곤 | - |
dc.contributor.author | 문현우 | - |
dc.date.accessioned | 2020-02-26T16:31:45Z | - |
dc.date.available | 2020-02-26T16:31:45Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/130292 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000424821 | en_US |
dc.description.abstract | A simple, rapid, accurate, precise and robust HPLC method was developed for the simultaneous determination of fimasartan and amlodipine in tablet dosage form. Furthermore, stability of active ingredients was evaluated under normal and stress conditions. The isocratic elution was accomplished by Nucleosil C18 column (250 mm x 4.6 mm, 5 μm) at 40°C. The mobile phase consisted of acetonitrile and 0.02 M monopotassium phosphate buffer (pH 2.2) in the ratio of 50:50 (v/v) was eluted at 1.0 ml/min. The eluent was monitored by the UV detector for fimasartan and amlodipine at 237 nm in 8 min detection time. The validation of HPLC method was carried out in accordance with the ICH guidelines. The results of stability test using the Arrhenius equation is set at about the validity period. | - |
dc.publisher | 한양대학교 | - |
dc.title | 가속/가혹 조건에서 피마살탄과 암로디핀 복합제의 안정성 평가 | - |
dc.title.alternative | Evaluation of stability of fimasartan and amlodipine in combination tablet at accelerated/stressed condition | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 문현우 | - |
dc.contributor.alternativeauthor | Moon, Hyeon Woo | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 약학과 | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 물리약학 | - |
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