Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김경수 | - |
dc.contributor.author | 박인화 | - |
dc.date.accessioned | 2020-02-18T16:32:02Z | - |
dc.date.available | 2020-02-18T16:32:02Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/126650 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000428837 | en_US |
dc.description.abstract | Background: A systemic treatment of granulocyte-colony stimulating factor (G-CSF) is known to improve healings of damaged tissues. However, recent studies suggested local actions of G-CSF on the healing processes of damaged tissues. We investigated the treatment effect of locally injected G-CSF and compared to that of systemically injected G-CSF in a rat skin excisional model. Methods and Results: A wound was created on the rat dorsum and treated either by local injection or by systemic injection of G-CSF. Wound healing rate, deposition of collagen, and gene expression were evaluated. G-CSF receptor (G-CSFR) protein was detected by Western blotting. The wound healing rate in the local injection group was significantly higher than that in the systemic injection group at days 9 and 15; it was also significantly higher than that in the control group at days 3, 9, and 15. The expression of G-CSFR protein in wound tissues was higher than in normal skin tissues. Conclusion: In conclusion, the local injection of G-CSF is more effective than systemic injection of G-CSF in promoting wound healing, which may implicate the local action of G-CSF treatment in wound healing processes. | - |
dc.publisher | 한양대학교 | - |
dc.title | 쥐 피부 창상모델에서 과립구형성자극인자의 국소투여로 인한 창상치유의 촉진효과 | - |
dc.title.alternative | Local injection of granulocyte-colony stimulating factor accelerates wound healing in a rat skin excisional wound model | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 박인화 | - |
dc.contributor.alternativeauthor | In-Hwa Park | - |
dc.sector.campus | S | - |
dc.sector.daehak | 의생명공학전문대학원 | - |
dc.sector.department | 임상의과학과 | - |
dc.description.degree | Master | - |
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