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The Role of CD82 in Mycobacterium tuberculosis Infection

Title
The Role of CD82 in Mycobacterium tuberculosis Infection
Other Titles
결핵균 감염에 대한 CD82 역할 연구
Author
고현정
Alternative Author(s)
고현정
Advisor(s)
양철수
Issue Date
2017-02
Publisher
한양대학교
Degree
Master
Abstract
Mycobacterium tuberculosis (Mtb) is able to replicate and survive in macrophage and suppress host immune response. But detailed mechanism that Mtb facilitates to enhance intracellular survival is unclear. Here, we found that Cluster of Differentiation 82 (CD82) plays critical role in Mtb intracellular survival and inflammation, and epigenetic modification participated in host anti-bacterial responses. CD82 expression is up-regulated significantly by Mtb virulent strain H37Rv, but slightly by Mtb avirulent strain H37Ra. In CD82-overexpression manner, various mycobacterial survival increased. In contrast, CD82 deficient condition, intracellular survival of mycobacteria decreased and antibacterial response enhances against Mtb infection. DNA methylation level in CD82 promoter region is changed by Mtb H37Rv infection. Mtb H37Ra infection increases DNA methyltransferases mRNA level. In addition, we show that DNA methylation inhibitor, 5-Aza-2’- deoxycytidine, treatment is concerned in increasing CD82 level. These data indicate that Mtb H37Rv is able to survive against host immune response by regulating DNA methylation of CD82 promoter region. Thus, the studies in roles of CD82 will provides opportunities for finding therapeutic candidates about tuberculosis.
URI
https://repository.hanyang.ac.kr/handle/20.500.11754/124917http://hanyang.dcollection.net/common/orgView/200000429805
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > MOLECULAR & LIFE SCIENCE(분자생명과학과) > Theses (Master)
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