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Preparation and evaluation of chitosan film-forming gel for transdermal aspirin delivery

Title
Preparation and evaluation of chitosan film-forming gel for transdermal aspirin delivery
Author
강종호
Advisor(s)
김진기
Issue Date
2017-02
Publisher
한양대학교
Degree
Master
Abstract
The aim of this study was to prepare and evaluate chitosan film-forming gel for transdermal aspirin delivery. Aspirin-loaded chitosan film-forming gel (ACFG) was prepared by mixing and stirring method using different concentrations of chitosan, and transdermal films were prepared from ACFG by casting method. The physicochemical properties of ACFG was evaluated in terms of film-forming time, hardness, viscosity and adhesiveness. The in vitro skin permeation of ACFG was evaluated using Franz diffusion cells. The mechanical properties of the transdermal films were evaluated in terms of tensile strength and elongation. On increasing chitosan concentration in ACFG as 3, 3.5, 4 and 4.5%, the film-forming time was reduced to 40.2, 30.0, 20.0 and 17.2 minutes, respectively. ACFG with 4 and 4.5% of chitosan was selected for measuring the physicochemical and mechanical properties. Hardness and viscosity of ACFG was increased with increasing concentration of chitosan. Adhesiveness of gel are influenced by the ratio of propylene glycol. Adhesion of gel was increased by increasing propylene glycol (PG) up to 7%. In addition, by increasing PG concentration, the tensile strength of films was reduced. However, elongation of films was increased by increasing PG concentration. ACFG showed better skin permeation as compared to aspirin-loaded Carbopol gel and aspirin solution. In conclusion, ACFG might be a potential transdermal delivery system for aspirin to reduce the side effects associated with oral administration of aspirin. Keywords: aspirin, chitosan, film-forming gel, transdermal delivery, antiplatelet drug.
URI
https://repository.hanyang.ac.kr/handle/20.500.11754/124473http://hanyang.dcollection.net/common/orgView/200000429719
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > PHARMACY(약학과) > Theses (Master)
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