Full metadata record
DC Field | Value | Language |
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dc.contributor.advisor | 김진기 | - |
dc.contributor.author | 김경원 | - |
dc.date.accessioned | 2020-02-11T02:15:24Z | - |
dc.date.available | 2020-02-11T02:15:24Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/123027 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000437015 | en_US |
dc.description.abstract | ABSTRACT Preparation of sorafenib nanosuspension based on high pressure homogenization technique for improved oral bioavailability Kyoung-Won Kim Department of Pharmacy The Graduate School Hanyang University Sorafenib (SRF) is a multiple kinase inhibitor approved for several cancers including hepatocellular carcinoma and advanced renal cell cancer. However, the oral bioavailability of SRF is excessively low (approximately 8.43%) due to its aqueous solubility. The objective of this study was to prepare sorafenib nanosuspensions (SRF-NSs) to improve dissolution and oral bioavailability with hydrophilic polymers as stabilizers and sodium lauryl sulfate (SLS) as a surfactant. SRF-NSs were prepared by combination of ultrasonication and high pressure homogenization technique, followed by lyophilization for storage stability and further processes. To optimize SRF-NSs, the main parameters such as ratios of stabilizers and SLS (w/w), ultrasonication time, homogenization pressure and cycles of high pressure homogenization were investigated. The physicochemical properties of SRF-NSs were evaluated for particle size, polydispersity index and zeta potential. The optimized SRF-NSs were characterized for surface morphology, crystallinity, dissolution in pH 1.2 and pH 6.8, and pharmacokinetics in rats. Hydroxypropyl cellulose (HPC), a water-soluble cellulose ether, was the most efficient hydrophilic polymer in the preparation of nanosuspensions. In particular, SRF-NSs prepared with SRF, Klucel™ HPC EXF, Tween 80 and SLS (10:5:2:1, weight ratio) showed the smallest particle size near 300 nm and low polydispersity index below 0.3 indicating a narrow particle size distribution. The optimized SRF-NSs showed an enhanced dissolution and oral bioavailability of SRF compared with SRF powder due to their reduced particle size and amorphous state conversion. Thus, SRF-NSs could be a promising strategy to enhance the oral bioavailability of SRF. Key words: Sorafenib, Nanosuspension, Dissolution, Oral bioavailability, High pressure homogenization | - |
dc.publisher | 한양대학교 | - |
dc.title | Preparation of sorafenib nanosuspension based on high pressure homogenization technique for improved oral bioavailability | - |
dc.type | Theses | - |
dc.contributor.googleauthor | Kyoung-Won Kim | - |
dc.contributor.alternativeauthor | 김경원 | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 약학과 | - |
dc.description.degree | Master | - |
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