Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손현 | - |
dc.date.accessioned | 2020-01-29T06:35:10Z | - |
dc.date.available | 2020-01-29T06:35:10Z | - |
dc.date.issued | 2019-01 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 116, NO 5, Page. 1770-1775 | en_US |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://www.pnas.org/content/116/5/1770 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/122314 | - |
dc.description.abstract | Major depressive disorder (MDD) is a devastating disease that arises in a background of environmental risk factors, such as chronic stress, that produce reactive oxygen species (ROS) in the brain. The chronic stress-induced ROS production involves Ca2+ signals; however, the mechanism is poorly understood. Transient receptor potential melastatin type 2 (TRPM2) is a Ca2+-permeable cation channel that is highly expressed in the brain. Here we show that in animal models of chronic unpredictable stress (CUS), deletion of TRPM2 (Trpm2(-/-)) produces antidepressant-like behaviors in mice. This phenotype correlates with reduced ROS, ROS-induced calpain activation, and enhanced phosphorylation of two Cdk5 targets including synapsin 1 and histone deacetylase 5 that are linked to synaptic function and gene expression, respectively. Moreover, TRPM2 mRNA expression is increased in hippocampal tissue samples from patients with MDD. Our findings suggest that TRPM2 is a key agent in stress-induced depression and a possible target for treating depression. | en_US |
dc.description.sponsorship | We thank Christopher W. Cowan and David S. Park for providing anti-HDAC5(Ser279) and anti-Prx2(Thr89), respectively. This work was supported by National Research Foundation of Korea Grants 2016R1A2B2006474 (to H.S.) and 2016R1A2B4013332 (to S.J.J.); Basic Science Research Program Grants 2017R1A6A3A01005765 (to S.E.W.) and 2017R1D1A1B03032858 (to M.C.); and Medical Research Center Grant 2017R1A5A2015395 (to H.S.) funded by the Ministry of Science and Technology, Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATL ACAD SCIENCES | en_US |
dc.subject | TRPM2 | en_US |
dc.subject | depression | en_US |
dc.subject | ROS | en_US |
dc.subject | Cdk5 | en_US |
dc.subject | neurogenesis | en_US |
dc.title | Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 116 | - |
dc.identifier.doi | 10.1073/pnas.1814335116 | - |
dc.relation.page | 1770-1775 | - |
dc.relation.journal | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.contributor.googleauthor | Ko, Seung Yeon | - |
dc.contributor.googleauthor | Wang, Sung Eun | - |
dc.contributor.googleauthor | Lee, Han Kyu | - |
dc.contributor.googleauthor | Jo, Sungsin | - |
dc.contributor.googleauthor | Han, Jinil | - |
dc.contributor.googleauthor | Lee, Seung Hoon | - |
dc.contributor.googleauthor | Choi, Miyeon | - |
dc.contributor.googleauthor | Jo, Hye-Ryeong | - |
dc.contributor.googleauthor | Seo, Jee Young | - |
dc.contributor.googleauthor | Son, Hyeon | - |
dc.relation.code | 2019002080 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hyeonson | - |
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