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Highly sensitive non-enzymatic lactate biosensor driven by porous nanostructured nickel oxide

Title
Highly sensitive non-enzymatic lactate biosensor driven by porous nanostructured nickel oxide
Author
박태주
Keywords
Lactate detection; Porous nickel oxide; Electrochemical sensor; Amperometric biosensor; Non-enzymatic biosensor
Issue Date
2019-12
Publisher
ELSEVIER SCI LTD
Citation
CERAMICS INTERNATIONAL, v. 45, No. 17, Page. 23370-23376
Abstract
Lactate sensors are increasingly used for applications in sports and clinical medicine, but currently have several shortcomings including low sensitivity. We demonstrate a highly sensitive and selective non-enzymatic lactate sensor based on porous nickel oxide by sol-gel based inverse micelle method. The porosity and surface area of nickel oxide depending on the calcination temperature (250, 350, and 450 degrees C) were compared using electron microscopy and a Brunauer-Emmett-Teller (BET) surface area analyzer. Furthermore, we also compared the chemical state of Ni3+ in porous nickel oxides, which is known to be strongly engaged with electrocatalytic lactate detection, with different calcination temperature. The sensing characteristics were assessed using an amperometric response with a three-electrode system. Owing to a relatively large surface area and high Ni3+/Ni2+ ratio, NiO calcined at 250 degrees C, exhibit maximum sensitivity at 62.35 mu A/mM (cm(2)), and a minimum detection of limit of 27 mu M, although, it has large amount of organic residue because of low calcination temperature. In addition to its sensitivity, a porous nickel oxide electrode also displays good selectivity against other interferents such as L-ascorbic acid, uric acid, and dopamine, further supporting its potential as a non-enzymatic lactate sensor.
URI
https://www.sciencedirect.com/science/article/pii/S0272884219322321https://repository.hanyang.ac.kr/handle/20.500.11754/122275
ISSN
0272-8842; 1873-3956
DOI
10.1016/j.ceramint.2019.08.037
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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