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Self-Assembling Peptides and Their Application in the Treatment of Diseases

Title
Self-Assembling Peptides and Their Application in the Treatment of Diseases
Author
류종석
Keywords
peptide; self-assembly; nanostructure; drug delivery; disease
Issue Date
2019-11
Publisher
MDPI
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, No. 23, Article no. 5850
Abstract
Self-assembling peptides are biomedical materials with unique structures that are formed in response to various environmental conditions. Governed by their physicochemical characteristics, the peptides can form a variety of structures with greater reactivity than conventional non-biological materials. The structural divergence of self-assembling peptides allows for various functional possibilities; when assembled, they can be used as scaffolds for cell and tissue regeneration, and vehicles for drug delivery, conferring controlled release, stability, and targeting, and avoiding side effects of drugs. These peptides can also be used as drugs themselves. In this review, we describe the basic structure and characteristics of self-assembling peptides and the various factors that affect the formation of peptide-based structures. We also summarize the applications of self-assembling peptides in the treatment of various diseases, including cancer. Furthermore, the in-cell self-assembly of peptides, termed reverse self-assembly, is discussed as a novel paradigm for self-assembling peptide-based nanovehicles and nanomedicines.
URI
https://www.mdpi.com/1422-0067/20/23/5850https://repository.hanyang.ac.kr/handle/20.500.11754/122153
ISSN
1422-0067
DOI
10.3390/ijms20235850
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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