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Acoustic Anomalies and Fast Relaxation Dynamics of Amorphous Progesterone as Revealed by Brillouin Light Scattering

Title
Acoustic Anomalies and Fast Relaxation Dynamics of Amorphous Progesterone as Revealed by Brillouin Light Scattering
Author
유효종
Keywords
progesterone; pharmaceutical; glass; Brillouin scattering; acoustic
Issue Date
2017-12
Publisher
MDPI AG
Citation
MATERIALS, v. 10, No. 12, Article no. 1426
Abstract
The amorphous state of pharmaceuticals has attracted much attention due to its high bioavailability and other advantages. The stability of the amorphous state in relation with the local molecular mobility is important from both fundamental and practical points of view. The acoustic properties of amorphous progesterone, one of the representative steroid hormones, were investigated by using a Brillouin inelastic light scattering technique. The Brillouin spectrum of the longitudinal acoustic mode exhibited distinct changes at the glass transition and the cold-crystallization temperatures. The acoustic dispersions of the longitudinal sound velocity and the acoustic absorption coefficient were attributed to the fast and possibly the secondary relaxation processes in the glassy and supercooled liquid states, while the structural relaxation process was considered as the dominant origin for the significant acoustic damping observed even in the liquid phase. The persisting acoustic dispersion in the liquid state was attributed to the single-molecule nature of the progesterone which does not exhibit hydrogen bonds in the condensed states.
URI
https://www.mdpi.com/1996-1944/10/12/1426https://repository.hanyang.ac.kr/handle/20.500.11754/121657
ISSN
1996-1944
DOI
10.3390/ma10121426
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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