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Combined photothermal and photodynamic therapy by hyaluronic acid-decorated polypyrrole nanoparticles

Title
Combined photothermal and photodynamic therapy by hyaluronic acid-decorated polypyrrole nanoparticles
Author
최한곤
Keywords
hyaluronic acid; IR-780; phototherapy; polypyrrole
Issue Date
2017-07
Publisher
FUTURE MEDICINE LTD
Citation
NANOMEDICINE, v. 12, No. 12, Page. 1511-1523
Abstract
Aim: To develop a nanoparticle-based platform using polypyrrole and IR-780 for effective combined photothermal and photodynamic therapy. Materials methods: IR-780 was loaded in a poly(lactic-co-glycolic acid) core, decorated with polypyrrole shells and hyaluronic acid (IPPH). Physicochemical properties and in vitro and in vivo anticancer effects of these nanoparticles were evaluated. Results: The resulting IPPHs were spherical, small and negatively charged. Under near-infrared laser irradiation, the IPPHs generated reactive oxygen species and heat and synergistically improved therapeutic efficacy. The antitumor effects were confirmed by in vitro cellular reactive oxygen species detection and cytotoxicity assays, and in vivo in a xenograft tumor model, with no damage to body organs. Conclusion: Our results indicate the potential of applying IPPH in oncology nanomedicine.
URI
https://www.futuremedicine.com/doi/abs/10.2217/nnm-2016-0438https://repository.hanyang.ac.kr/handle/20.500.11754/121640
ISSN
1743-5889; 1748-6963
DOI
10.2217/nnm-2016-0438
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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