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dc.contributor.author한진영-
dc.date.accessioned2019-12-31T01:19:43Z-
dc.date.available2019-12-31T01:19:43Z-
dc.date.issued2018-09-
dc.identifier.citationMETHODS OF INFORMATION IN MEDICINE, v. 57, No. 4, Page. 208-219en_US
dc.identifier.issn0026-1270-
dc.identifier.issn2511-705X-
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/html/10.3414/ME17-02-0012-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/121429-
dc.description.abstractBackground: As healthcare increasingly digitizes, streaming waveform data is being made available from an variety of sources, but there still remains a paucity of performant clinical decision support systems. For example, in the intensive care unit (ICU) existing automated alarm systems typically rely on simple thresholding that result in frequent false positives. Recurrent false positive alerts create distrust of alarm mechanisms that can be directly detrimental to patient health. To improve patient care in the ICU, we need alert systems that are both pervasive, and accurate so as to be informative and trusted by providers. Objective: We aimed to develop a machine learning-based classifier to detect abnormal waveform events using the use case of mechanical ventilation waveform analysis, and the detection of harmful forms of ventilation delivery to patients. We specifically focused on detecting injurious subtypes of patient-ventilator asynchrony (PVA). Methods: Using a dataset of breaths recorded from 35 different patients, we used machine learning to create computational models to automatically detect, and classify two types of injurious PVA, double trigger asynchrony (DTA), breath stacking asynchrony (BSA). We examined the use of synthetic minority over-sampling technique (SMOTE) to overcome class imbalance problems, varied methods for feature selection, and use of ensemble methods to optimize the performance of our model. Results: We created an ensemble classifier that is able to accurately detect DTA at a sensitivity/specificity of 0.960/0.975, BSA at sensitivity/specificity of 0.944/0.987, and non-PVA events at sensitivity/specificity of .967/.980. Conclusions: Our results suggest that it is possible to create a high-performing machine learning-based model for detecting PVA in mechanical ventilator waveform data in spite of both intra-patient, and inter-patient variability in waveform patterns, and the presence of clinical artifacts like cough and suction procedures. Our work highlights the importance of addressing class imbalance in clinical data sets, and the combined use of statistical methods and expert knowledge in feature selection.en_US
dc.description.sponsorshipThis work was generously supported by the National Heart, Lung, and Blood Institute Emergency Medicine K12 Clinical Research Training Program (K12 HL108964), the Center for Information Technology Research in the Interest of Society (2014-227 and 2015-325), by the UC Davis Clinical and Translational Science Center, and by the National Center for Advancing Translational Sciences, National Institutes of Health (UL1 TR001860). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.en_US
dc.language.isoen_USen_US
dc.publisherSCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTENen_US
dc.subjectPatient ventilator asynchronyen_US
dc.subjectartificial respirationen_US
dc.subjectmachine learningen_US
dc.subjectintensive care unitsen_US
dc.subjectclinical decision support systemsen_US
dc.titleCreation of a Robust and Generalizable Machine Learning Classifier for Patient Ventilator Asynchronyen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume57-
dc.identifier.doi10.3414/ME17-02-0012-
dc.relation.page208-219-
dc.relation.journalMETHODS OF INFORMATION IN MEDICINE-
dc.contributor.googleauthorRehm, Gregory B.-
dc.contributor.googleauthorHang, Jinyoung-
dc.contributor.googleauthorKuhn, Brooks T.-
dc.contributor.googleauthorDelplanque, Jean-Pierre-
dc.contributor.googleauthorAnderson, Nicholas R.-
dc.contributor.googleauthorAdams, Jason Y.-
dc.contributor.googleauthorChuah, Chen-Nee-
dc.relation.code2018002996-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF COMPUTING[E]-
dc.sector.departmentDIVISION OF MEDIA, CULTURE, AND DESIGN TECHNOLOGY-
dc.identifier.pidjinyounghan-
Appears in Collections:
COLLEGE OF COMPUTING[E](소프트웨어융합대학) > MEDIA, CULTURE, AND DESIGN TECHNOLOGY(ICT융합학부) > Articles
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