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dc.contributor.author황승용-
dc.date.accessioned2019-12-10T19:41:35Z-
dc.date.available2019-12-10T19:41:35Z-
dc.date.issued2018-12-
dc.identifier.citationSLAS TECHNOLOGY, v. 23, no. 6, page. 507-515en_US
dc.identifier.issn2472-6303-
dc.identifier.issn2472-6311-
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/2472630318783948-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/121111-
dc.description.abstractInfertile couples needing assisted reproduction are increasing, so a fundamental understanding of motile sperm migration is required. This paper presents an advanced microfluidic device for sperm motion analysis utilizing chemotaxis and thermotaxis simultaneously for the first time. The proposed device is a transparent polydimethylsiloxane- and glass-based microfluidic chip system providing a low-cost, useful, and disposable platform for sperm analysis. The concentration gradient of the chemoattractant (acetylcholine) and the temperature difference are formed along the microchannel. The temperature gradient is generated and controlled by a microheater and microsensor. Thermotactic and chemotactic responses of mouse sperm were examined using the proposed device. Experimental results show that motile mouse sperm are attracted more sensitively under integrated conditions of chemotaxis and thermotaxis rather than individual conditions of chemotaxis and thermotaxis. This sperm analysis device is expected to be a useful tool for the study of mammalian sperm migration and the improvement of artificial insemination techniques.en_US
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2015R1A2A2A01006088) and by the NRF grant funded by the Korean government (MSIT) (no. 2018R1A2B6003661).en_US
dc.language.isoen_USen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.subjectthermotaxisen_US
dc.subjectchemotaxisen_US
dc.subjectmouse sperm migrationen_US
dc.subjectmicrofluidicsen_US
dc.subjectsperm analyzeren_US
dc.titleDesign, Fabrication, and Testing of a Microfluidic Device for Thermotaxis and Chemotaxis Assays of Spermen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume23-
dc.identifier.doi10.1177/2472630318783948-
dc.relation.page507-515-
dc.relation.journalSLAS TECHNOLOGY-
dc.contributor.googleauthorKo, Yong-Jun-
dc.contributor.googleauthorMaeng, Joon-Ho-
dc.contributor.googleauthorHwang, Seung Yong-
dc.contributor.googleauthorAhn, Yoomin-
dc.relation.code2018004168-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidsyhwang-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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