Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강주섭 | - |
dc.date.accessioned | 2019-12-10T19:31:36Z | - |
dc.date.available | 2019-12-10T19:31:36Z | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | THERAPEUTIC DRUG MONITORING, v. 40, no. 6, page. 754-758 | en_US |
dc.identifier.issn | 0163-4356 | - |
dc.identifier.issn | 1536-3694 | - |
dc.identifier.uri | http://insights.ovid.com/pubmed?pmid=30045358&clickthrough=y | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/121098 | - |
dc.description.abstract | Background: Limited sampling strategy (LSS) is a validated method to estimate pharmacokinetic (PK) parameters from a reduced number of samples. Omeprazole is used to phenotype in vivo cytochrome P450 (CYP) 2C19 activity. This study examined an LSS using 2 estimation methods to determine apparent oral clearance (CL/F) and thus CYP2C19 activity. Methods: Data from 7 previously published studies included healthy subjects receiving a single, oral dose of omeprazole with intensive PK sampling. CL/F was estimated using noncompartmental analysis (NCA) and population PK modeling. LSS was simulated by selecting the 1, 2, 4, and/or 6-hour postdose time points. Linear regression was performed to assess whether CL/F estimated from limited sampling could accurately predict CL/F from the full PK profile. Results: Median CL/F was 23.7 L/h by NCA and 19.3 L/h by population PK modeling. In comparing the LSS NCA estimated versus observed CL/F, all evaluated linear regression models had unacceptable coefficients of determination (r(2), range: 0.14-0.81). With the population PK approach, 737 plasma concentrations (n = 71) and CYP2C19 genotype data were described with a 1-compartment structural model with mixed zero and first-order absorption and lag time. In comparing the population PK LSS estimated versus observed CL/F, all evaluated linear regression models had unacceptable r(2) (range: 0.02-0.74). Post hoc comparison of CYP2C19 poor metabolizers versus CYP2C19 extensive metabolizers resulted in significantly lower CL/F in poor metabolizers versus extensive metabolizers. Conclusions: Omeprazole LSS performed poorly in estimating CL/F using 2 separate estimation approaches and does not seem to be a suitable method for determining CYP2C19 activity. | en_US |
dc.description.sponsorship | S. Lin was a post-doctoral fellow with funding supported by Pfizer Global Research and Development and the UCSD, Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA. Funding support was provided by a Research in Pediatric and Developmental Pharmacology NIH grant (1U54HD090259-01 to E.V.C.). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.subject | cytochrome P450 | en_US |
dc.subject | omeprazole | en_US |
dc.subject | limited sampling strategy | en_US |
dc.subject | CYP2C19 | en_US |
dc.title | Evaluation of Omeprazole Limited Sampling Strategies to Estimate Constitutive Cytochrome P450 2C19 Activity in Healthy Adults | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 40 | - |
dc.relation.page | 754-758 | - |
dc.relation.journal | THERAPEUTIC DRUG MONITORING | - |
dc.contributor.googleauthor | Lin, Swan | - |
dc.contributor.googleauthor | Nikanjam, Mina | - |
dc.contributor.googleauthor | Capparelli, Edmund V. | - |
dc.contributor.googleauthor | Allegrini, Alessandro | - |
dc.contributor.googleauthor | Pavone, Daniele | - |
dc.contributor.googleauthor | Yim, Dong-Seok | - |
dc.contributor.googleauthor | Hammami, Muhammad M. | - |
dc.contributor.googleauthor | Bertino, Joseph S. | - |
dc.contributor.googleauthor | Nafziger, Anne N. | - |
dc.contributor.googleauthor | Kang, Ju-Seop | - |
dc.relation.code | 2018003576 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jskang | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.