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dc.contributor.author채필석-
dc.date.accessioned2019-12-10T16:39:11Z-
dc.date.available2019-12-10T16:39:11Z-
dc.date.issued2018-12-
dc.identifier.citationANALYST, v. 143, no. 23, page. 5702-5710en_US
dc.identifier.issn0003-2654-
dc.identifier.issn1364-5528-
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2018/AN/C8AN01408F#!divAbstract-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/121042-
dc.description.abstractThe study of membrane proteins is extremely challenging, mainly because of the incompatibility of the hydrophobic surfaces of membrane proteins with an aqueous medium. Detergents are essential agents used to maintain membrane protein stability in non-native environments. However, conventional detergents fail to stabilize the native structures of many membrane proteins. Development of new amphipathic agents with enhanced efficacy for membrane protein stabilization is necessary to address this important problem. We have designed and synthesized linear and branched mannitol-based amphiphiles (MNAs), and comparative studies showed that most of the branched MNAs had advantages over the linear agents in terms of membrane protein stability. In addition, a couple of the new MNAs displayed favorable behaviors compared to n-dodecyl-beta-D-maltoside and the previously developed MNAs in maintaining the native protein structures, indicating potential utility of these new agents in membrane protein study.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (grant number 2016R1A2B2011257 to P. S. C.) and by the National Institutes of Health grant R01GM122759 to L.G.en_US
dc.language.isoen_USen_US
dc.publisherROYAL SOC CHEMISTRYen_US
dc.subjectRESONANCE ENERGY-TRANSFERen_US
dc.subjectGLYCOL GNG AMPHIPHILESen_US
dc.subjectCRYSTAL-STRUCTUREen_US
dc.subjectFACIAL AMPHIPHILESen_US
dc.subjectMELIBIOSE PERMEASEen_US
dc.subjectESCHERICHIA-COLIen_US
dc.subjectMNG AMPHIPHILESen_US
dc.subjectSOLUTION NMRen_US
dc.subjectCRYSTALLIZATIONen_US
dc.subjectDETERGENTSen_US
dc.titleA comparative study of branched and linear mannitol-based amphiphiles on membrane protein stabilityen_US
dc.typeArticleen_US
dc.relation.no23-
dc.relation.volume143-
dc.identifier.doi10.1039/c8an01408f-
dc.relation.page5702-5710-
dc.relation.journalANALYST-
dc.contributor.googleauthorHussain, Hazrat-
dc.contributor.googleauthorHelton, Tyler-
dc.contributor.googleauthorDu, Yang-
dc.contributor.googleauthorMortensen, Jonas S.-
dc.contributor.googleauthorHariharan, Parameswaran-
dc.contributor.googleauthorEhsan, Muhammad-
dc.contributor.googleauthorByrne, Bernadette-
dc.contributor.googleauthorLoland, Claus J.-
dc.contributor.googleauthorKobilka, Brian K.-
dc.contributor.googleauthorChae, Pil Seok-
dc.relation.code2018001992-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidpchae-
dc.identifier.orcidhttp://orcid.org/0000-0003-1799-3304-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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