Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박진규 | - |
dc.date.accessioned | 2019-12-10T15:09:51Z | - |
dc.date.available | 2019-12-10T15:09:51Z | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 8, Article no. 18039 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/s41598-018-36185-7 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120964 | - |
dc.description.abstract | Exercise intolerance among the clinical symptoms in patients with atrial fibrillation (AF) has usually been masked by their adjusted life style. We sought to assess the role of CHA(2)DS(2)-VASc score to predict exercise intolerance in asymptomatic AF patients, and further examine whether the relationship differs by age and gender. Among the 6,275 participants of the prospective Korean registry of the Comparison study of Drugs for symptom control and complication prevention of Atrial Fibrillation (CODE-AF), 1,080 AF patients who underwent exercise treadmill testing were studied. Exercise intolerance was defined as a peak exercise capacity of 7 metabolic equivalents (METs) or less, and the patients were divided into two groups for the analysis: <= 7 METs (n = 131) and >7 METs (n = 949). Patients with exercise intolerance had a significantly higher CHA(2)DS(2)-VASc score than those without (3.1 +/- 1.3 vs. 2.0 +/- 1.5, p < 0.0001). In the multivariate analysis, a higher CHA(2)DS(2)-VASc score (OR 1.54, 95% CI 1.31-1.81, p < 0.0001), corrected QT interval (OR 1.01, 95% CI 1.00-1.02, p = 0.026), and increased left atrial volume index (OR 1.02, 95% CI 1.01-1.03, p = 0.001) were found to be independent predictors of exercise intolerance. The impact of the CHA(2)DS(2)-VASc score on exercise intolerance was significant only in male patients aged < 65 years (OR 3.30, 95% CI 1.76-6.19, p < 0.0001). The CHA(2)DS(2)-VASc score may be a feasible risk assessment tool to predict exercise intolerance, especially in young and middle-aged male patients with asymptomatic AF. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Healthcare Technology R & D project funded by the Ministry of Health & Welfare (H15C1200), and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2017R1E1A1A01078382). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | QUALITY-OF-LIFE | en_US |
dc.subject | HEART-FAILURE | en_US |
dc.subject | CARDIAC REHABILITATION | en_US |
dc.subject | CAPACITY | en_US |
dc.subject | MORTALITY | en_US |
dc.subject | PERSISTENT | en_US |
dc.subject | MANAGEMENT | en_US |
dc.subject | OUTCOMES | en_US |
dc.subject | RISK | en_US |
dc.subject | CARDIOLOGY | en_US |
dc.title | CHA(2)DS(2)-VASc score predicts exercise intolerance in young and middle-aged male patients with asymptomatic atrial fibrillation | en_US |
dc.type | Article | en_US |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.1038/s41598-018-36185-7 | - |
dc.relation.page | 1-8 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Yi, Jeong-Eun | - |
dc.contributor.googleauthor | Lee, Young Soo | - |
dc.contributor.googleauthor | Choi, Eue-Keun | - |
dc.contributor.googleauthor | Cha, Myung-Jin | - |
dc.contributor.googleauthor | Kim, Tae-Hoon | - |
dc.contributor.googleauthor | Park, Jin-Kyu | - |
dc.contributor.googleauthor | Lee, Jung-Myung | - |
dc.contributor.googleauthor | Kang, Ki-Woon | - |
dc.contributor.googleauthor | Shim, Jaemin | - |
dc.contributor.googleauthor | Uhm, Jae-Sun | - |
dc.relation.code | 2018003596 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | cardiohy | - |
dc.identifier.orcid | http://orcid.org/0000-0001-7931-777X | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.