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Pd(II)/Cu(II)-Catalyzed Regio- and Stereoselective Synthesis of (E)-3-Arylmethyleneisoindolin-1-ones Using Air as the Terminal Oxidant

Title
Pd(II)/Cu(II)-Catalyzed Regio- and Stereoselective Synthesis of (E)-3-Arylmethyleneisoindolin-1-ones Using Air as the Terminal Oxidant
Author
윤소원
Keywords
ONE-POT SYNTHESIS; C-H ACTIVATION; POSSESSING INHIBITORY-ACTIVITY; MIYAURA DOMINO REACTIONS; ALIPHATIC AMIDES; HIGHLY REGIO; INTRAMOLECULAR CYCLIZATION; REGIOSELECTIVE SYNTHESIS; OXIDATIVE OLEFINATION; CATALYZED ANNULATION
Issue Date
2018-12
Publisher
AMER CHEMICAL SOC
Citation
ORGANIC LETTERS, v. 20, no. 24, page. 7869-7874
Abstract
Regio- and stereoselective synthesis of (E)-3-arylmethyleneisoindolin-1-ones via Pd(II)/Cu(II)-catalyzed one pot C-C/C-N bond forming sequence between amides and styrenes is reported. This method provides facile and rapid access to a diverse range of such compounds using readily available starting materials under mild aerobic conditions with good functional group tolerance and high selectivity and efficiency. Further elaboration of the products obtained from this process enabled very short and efficient syntheses of aristolactam and indoloisoquinolinone alkaloids.
URI
https://pubs.acs.org/doi/10.1021/acs.orglett.8b03409https://repository.hanyang.ac.kr/handle/20.500.11754/120962
ISSN
1523-7060; 1523-7052
DOI
10.1021/acs.orglett.8b03409
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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