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Three dimensional neuro-retinal rim thickness and retinal nerve fiber layer thickness using high-definition optical coherence tomography for open-angle glaucoma

Title
Three dimensional neuro-retinal rim thickness and retinal nerve fiber layer thickness using high-definition optical coherence tomography for open-angle glaucoma
Author
이원준
Keywords
Unilateral open-angle glaucoma; High-definition optical coherence tomography; End point of Bruch`s membrane; Vitreo-retinal interface; Three-dimensional neuro-retinal rim thickness mapping
Issue Date
2018-11
Publisher
SPRINGER JAPAN KK
Citation
JAPANESE JOURNAL OF OPHTHALMOLOGY, v. 62, no. 6, page. 634-642
Abstract
PurposeTo compare the diagnostic capability of three-dimensional (3D) neuro-retinal rim thickness (NRR) with existing optic nerve head and retinal nerve fiber layer (RNFL) scan parameters using high-definition optical coherence tomography (HD-OCT).DesignRetrospective study.MethodsBased on the mean deviation (MD) of the Humphrey Field Analyzer (HFA), the 152 subjects were categorized into mild (MD >-6dB, 100), moderate (MD -6 to -12dB, 26), and severe (MD <-12dB, 26) glaucoma. The HD-OCT values of NRR, RNFL and ganglion cell inner plexiform layer (GCIPL) thicknesses, along with those of other parameters (rim area, disc area) were obtained, and the average NRR thickness was calculated.ResultsFor all of the HD-OCT parameters, RNFL thickness showed a higher area under the ROC (AUROC) curve (range: 0.937-1.000) than did NRR thickness (range: 0.827-1.000). There were significant RNFL, NRR, and GCIPL AUROC curve differences among the mild, moderate and severe glaucoma groups. RNFL thickness for mild glaucoma showed a significantly larger area than did NRR thickness [area difference: 0.110 (0.025); p value <0.0001). Furthermore, RNFL relative to NRR thickness yielded higher sensitivity (85-100% vs. 72-100%) and specificity (89-100% vs. 84-100%) for diagnosis of glaucoma.Conclusion RNFL thickness remains significantly better than 3D NRR thickness in terms of glaucoma-diagnostic capability in HD-OCT.
URI
https://link.springer.com/article/10.1007%2Fs10384-018-0620-7https://repository.hanyang.ac.kr/handle/20.500.11754/120792
ISSN
0021-5155; 1613-2246
DOI
10.1007/s10384-018-0620-7
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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