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Focal therapy versus robot-assisted partial nephrectomy in the management of clinical T1 renal masses A systematic review and meta-analysis

Title
Focal therapy versus robot-assisted partial nephrectomy in the management of clinical T1 renal masses A systematic review and meta-analysis
Author
박성열
Keywords
ablation techniques; kidney; meta-analysis; nephrectomy; robotics
Issue Date
2018-11
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
MEDICINE, v. 97, no. 45, Article no. e13102
Abstract
Background: Robot-assisted partial nephrectomy (RPN) and focal therapy (FT) have both been successfully employed in the management of small renal masses. However, despite this being the era of minimally invasive surgery, few comparative studies exist on RPN and FT. The aim of our study is to review perioperative, renal functional and oncologic outcomes of FT and RPN in cT1 renal masses.Methods: Literature published in Medline, EMBASE, and Cochrane Library databases up to April 22, 2018, was systematically searched. We included literature comparing outcomes of FT (radiofrequency ablation, cryoablation, microwave ablation, and irreversible electroporation) and RPN. Studies that reported only on laparoscopic partial nephrectomy or open partial nephrectomy, and review articles, editorials, letters, or cost analyses were excluded. In total, data from 1166 patients were included.Results: From 858 total articles, 7 nonrandomized, observational studies were included. Compared with RPN, FT was associated with a significantly lower decrease of estimated glomerular filtration rate (weighted mean difference [WMD] -8.06mL/min/1.73m(2); confidence interval [CI]-15.85 to-0.26; P=.04), and lower estimated blood loss (WMD -49.61mL; CI-60.78 to -38.45; P<.001). However, patients who underwent FT had a significantly increased risk of local recurrence (risk ratio [RR] 9.89; CI 4.24-23.04; P<.001) and distant metastasis (RR 6.42; CI 1.70-24.33; P=.006). However, operative times, lengths of stay, and complication rates were revealed to be similar between FT and RPN.Conclusion: RPN has a substantial advantage in preventing cancer recurrence. However, in the era of minimally invasive surgery, FT has advantages in renal function preservation and less bleeding. Long-term follow-up for survival rates and comparative analysis of microwave ablation and irreversible electroporation are needed to extend FT for patients with significant morbidities and for those who need sufficient renal function preservation with minimal bleeding.
URI
https://insights.ovid.com/crossref?an=00005792-201811090-00044https://repository.hanyang.ac.kr/handle/20.500.11754/120614
ISSN
0025-7974; 1536-5964
DOI
10.1097/MD.0000000000013102
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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