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dc.contributor.author정승준-
dc.date.accessioned2019-12-10T00:47:08Z-
dc.date.available2019-12-10T00:47:08Z-
dc.date.issued2018-11-
dc.identifier.citationANALYTICAL CHEMISTRY, v. 90, no. 22, page. 13348-13355en_US
dc.identifier.issn0003-2700-
dc.identifier.issn1520-6882-
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.analchem.8b02920-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/120545-
dc.description.abstractAlthough fast-scan cyclic voltammetry (FSCV) has been widely used for in vivo neurochemical detection, the sensitivity and selectivity of the technique can be further improved. In this study, we develop fast cyclic square-wave voltammetry (FCSWV) as a novel voltammetric technique that combines large-amplitude cyclic square-wave voltammetry (CSWV) with background subtraction. A large-amplitude, square-shaped potential was applied to induce cycling through multiple redox reactions within a square pulse to increase sensitivity and selectivity when combined with a two-dimensional voltammogram. As a result, FCSWV was significantly more sensitive than FSCV (n = 5 electrodes, two-way ANOVA, p = 0.0002). In addition, FCSWV could differentiate dopamine from other catecholamines (e.g., epinephrine and norepinephrine) and serotonin better than conventional FSCV. With the confirmation that FCSWV did not influence local neuronal activity, despite the large amplitude of the square waveform, it could monitor electrically induced phasic changes in dopamine release in rat striatum before and after injecting nomifensine, a dopamine reuptake inhibitor.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. NRF-2017R1A2B2006896).en_US
dc.language.isoen_USen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.subjectCARBON-FIBER MICROELECTRODESen_US
dc.subjectPAIRED-PULSE VOLTAMMETRYen_US
dc.subjectREAL-TIME MEASUREMENTen_US
dc.subjectEXTRACELLULAR DOPAMINEen_US
dc.subjectBRAINen_US
dc.subjectADSORPTIONen_US
dc.subjectFORMen_US
dc.subjectQUANTIFICATIONen_US
dc.subjectFLUCTUATIONSen_US
dc.subjectADENOSINEen_US
dc.titleFast Cyclic Square-Wave Voltammetry To Enhance Neurotransmitter Selectivity and Sensitivityen_US
dc.typeArticleen_US
dc.relation.no22-
dc.relation.volume90-
dc.identifier.doi10.1021/acs.analchem.8b02920-
dc.relation.page13348-13355-
dc.relation.journalANALYTICAL CHEMISTRY-
dc.contributor.googleauthorPark, Cheonho-
dc.contributor.googleauthorOh, Yoonbae-
dc.contributor.googleauthorShin, Hojin-
dc.contributor.googleauthorKim, Jaekyung-
dc.contributor.googleauthorKang, Yumin-
dc.contributor.googleauthorSim, Jeongeun-
dc.contributor.googleauthorCho, Hyun U.-
dc.contributor.googleauthorLee, Han Kyu-
dc.contributor.googleauthorJung, Sung Jun-
dc.contributor.googleauthorBlaha, Charles D.-
dc.relation.code2018002904-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pideurijj-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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