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Fast Cyclic Square-Wave Voltammetry To Enhance Neurotransmitter Selectivity and Sensitivity

Title
Fast Cyclic Square-Wave Voltammetry To Enhance Neurotransmitter Selectivity and Sensitivity
Author
정승준
Keywords
CARBON-FIBER MICROELECTRODES; PAIRED-PULSE VOLTAMMETRY; REAL-TIME MEASUREMENT; EXTRACELLULAR DOPAMINE; BRAIN; ADSORPTION; FORM; QUANTIFICATION; FLUCTUATIONS; ADENOSINE
Issue Date
2018-11
Publisher
AMER CHEMICAL SOC
Citation
ANALYTICAL CHEMISTRY, v. 90, no. 22, page. 13348-13355
Abstract
Although fast-scan cyclic voltammetry (FSCV) has been widely used for in vivo neurochemical detection, the sensitivity and selectivity of the technique can be further improved. In this study, we develop fast cyclic square-wave voltammetry (FCSWV) as a novel voltammetric technique that combines large-amplitude cyclic square-wave voltammetry (CSWV) with background subtraction. A large-amplitude, square-shaped potential was applied to induce cycling through multiple redox reactions within a square pulse to increase sensitivity and selectivity when combined with a two-dimensional voltammogram. As a result, FCSWV was significantly more sensitive than FSCV (n = 5 electrodes, two-way ANOVA, p = 0.0002). In addition, FCSWV could differentiate dopamine from other catecholamines (e.g., epinephrine and norepinephrine) and serotonin better than conventional FSCV. With the confirmation that FCSWV did not influence local neuronal activity, despite the large amplitude of the square waveform, it could monitor electrically induced phasic changes in dopamine release in rat striatum before and after injecting nomifensine, a dopamine reuptake inhibitor.
URI
https://pubs.acs.org/doi/10.1021/acs.analchem.8b02920https://repository.hanyang.ac.kr/handle/20.500.11754/120545
ISSN
0003-2700; 1520-6882
DOI
10.1021/acs.analchem.8b02920
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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