Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2019-12-09T21:02:11Z | - |
dc.date.available | 2019-12-09T21:02:11Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.citation | FRONTIERS IN ONCOLOGY, v. 8, Article no. 552 | en_US |
dc.identifier.issn | 2234-943X | - |
dc.identifier.uri | https://www.frontiersin.org/articles/10.3389/fonc.2018.00552/full | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120512 | - |
dc.description.abstract | We had previously reported anticancer activity in the water extract (WEX) of Ashwagandha leaves, and identified Triethylene glycol (TEG) as an active tumor suppressor component. In this study, we investigated anti-migratory and anti-angiogenesis activities of WEX and TEG. We conducted in vitro and in vivo experiments using TEG, and its two derivatives, Triethyleneglycol dimethacrylate (TD-10), and Tetraethyleneglycol dimethacrylate (TD-11). The data revealed strong anticancer and anti-metastasis potentials in the derivatives. Non-toxic, anti-migratory doses of the derivatives showed inhibition of canonical Wnt/beta-catenin axis and consequent downregulation of EMT-signaling proteins (Vimentin, MMPs and VEGF). These results endorse that the TD-10 and TD-11 have potential to safely put a check on the aggressiveness of the metastatic cells and therefore represent promising candidates for the treatment of metastatic cancers. | en_US |
dc.description.sponsorship | This work was supported by grants from the National Institute of Advanced Industrial Science & Technology (AIST)-DAILAB Special Fund (to SK and RW) and National Research Foundation of Korea (2016M3A9B5942352 and KDDF-201611-05 to C-OY). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | FRONTIERS MEDIA SA | en_US |
dc.subject | Ashwagandha | en_US |
dc.subject | TEG | en_US |
dc.subject | TEG-derivatives | en_US |
dc.subject | cell migration | en_US |
dc.subject | invasion | en_US |
dc.subject | metastasis | en_US |
dc.subject | therapy | en_US |
dc.title | Identification and Functional Characterization of Anti-metastasis and Anti-angiogenic Activities of Triethylene Glycol Derivatives | en_US |
dc.type | Article | en_US |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.3389/fonc.2018.00552 | - |
dc.relation.page | 552-563 | - |
dc.relation.journal | FRONTIERS IN ONCOLOGY | - |
dc.contributor.googleauthor | Oh, Eonju | - |
dc.contributor.googleauthor | Garg, Sukant | - |
dc.contributor.googleauthor | Liu, Ye | - |
dc.contributor.googleauthor | Afzal, Sajal | - |
dc.contributor.googleauthor | Gao, Ran | - |
dc.contributor.googleauthor | Yun, Chae-Ok | - |
dc.contributor.googleauthor | Kaul, Sunil C. | - |
dc.contributor.googleauthor | Wadhwa, Renu | - |
dc.relation.code | 2018011076 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | chaeok | - |
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