Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박병배 | - |
dc.date.accessioned | 2019-12-09T19:48:41Z | - |
dc.date.available | 2019-12-09T19:48:41Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | ANNALS OF HEMATOLOGY, v. 97, no. 10, page. 1851-1857 | en_US |
dc.identifier.issn | 0939-5555 | - |
dc.identifier.issn | 1432-0584 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs00277-018-3387-5 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120423 | - |
dc.description.abstract | Both-side synchronous involvement has been reported to account for 7-24% of ocular adnexal marginal zone lymphoma (OAML). We conducted a retrospective analysis to identify the clinical features and treatment outcomes of synchronous bilateral OAML (SB-OAML) by treatment modality. We analyzed patients with a histologic diagnosis of SB-OAML, excluding metachronous bilateral involved OAML. We enrolled a total of 95 patients for this analysis, 36 males and 59 females; the median patient age was 42 years (range 16-77 years). Eleven (11.6%) patients had been treated with chemotherapy or chemo-immunotherapy (eight R-CVP, two CVP, and one R-CHOP). The median number of treatments was 6 (range 6-8); there were 9 complete responses (CRs; 81.8%) and 2 partial responses (PRs; 18.2%). Nearly all patients (88.4%) received radiotherapy in both eyes, and the median radiation dose was 27 Gy (range 20-40 Gy) to each eye; 68 CRs (80.9%) and 14 PRs (16.7%) were achieved. Ten-year progression-free survival (PFS) and overall survival (OS) rates were 79.8 and 91.1%, respectively. Radiotherapy continued to be an independent prognostic marker, with the hazard of progression (P = 0.036). Eleven patients (13.1%) had surgery for cataract treatment during follow-up, and patients who received low-dose radiation (< 30.3 Gy) experienced fewer cataract operations. SB-OAML was predominantly observed in young females, and they had good response and prognosis regardless of treatment modalities. Low-dose radiotherapy to both eyes showed a tendency of longer PFS than did chemotherapy and could decrease cataract operations. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | Ocular adnexal marginal zone lymphoma | en_US |
dc.subject | Synchronous | en_US |
dc.subject | Bilateral | en_US |
dc.title | Treating synchronous bilateral ocular adnexal marginal zone lymphoma: the consortium for improving survival of lymphoma study | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 97 | - |
dc.identifier.doi | 10.1007/s00277-018-3387-5 | - |
dc.relation.page | 1851-1857 | - |
dc.relation.journal | ANNALS OF HEMATOLOGY | - |
dc.contributor.googleauthor | Oh, Sung Yong | - |
dc.contributor.googleauthor | Kim, Won Seog | - |
dc.contributor.googleauthor | Kang, Hye-Jin | - |
dc.contributor.googleauthor | Lee, Ji Hyun | - |
dc.contributor.googleauthor | Huh, Seokjae | - |
dc.contributor.googleauthor | Kim, Seokjin | - |
dc.contributor.googleauthor | Yoon, Dok Hyun | - |
dc.contributor.googleauthor | Hong, Jung Yong | - |
dc.contributor.googleauthor | Lee, Won Sik | - |
dc.contributor.googleauthor | Park, Byeong-Bae | - |
dc.relation.code | 2018000310 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | bbpark | - |
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