Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2019-12-09T19:01:18Z | - |
dc.date.available | 2019-12-09T19:01:18Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | CLINICAL RHEUMATOLOGY, v. 37, no. 10, page. 2875-2879 | en_US |
dc.identifier.issn | 0770-3198 | - |
dc.identifier.issn | 1434-9949 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs10067-018-4278-9 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120381 | - |
dc.description.abstract | We aimed to analyze the causal association between coffee consumption and the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), MR-Egger regression, and weighted median methods. We used publicly available summary statistics datasets of coffee consumption genome-wide association studies (GWASs) as an exposure variable and RA and SLE GWASs as outcomes. Four single-nucleotide polymorphisms (SNPs) from GWASs of coffee consumption were selected as instrumental variables (IVs) to improve inference: NCARD (rs16868941), POR (rs17685), CYP1A1 (rs2470893), and LAMB4 (rs382140). The IVW method showed a causal association between coffee consumption and RA (beta = 0.770, SE = 0.279, p = 0.006). MR-Egger regression revealed that directional pleiotropy was unlikely to be biasing the result (intercept = - 0.145, p = 0.451). While the MR-Egger analysis showed no causal association between coffee consumption and RA (beta = 2.744, SE = 1.712, p = 0.355), the weighted median approach demonstrated a causal association between coffee consumption and RA (beta = 0.751, SE = 0.348, p = 0.031). However, the associations based on the weighted median analyses after the Bonferroni correction were not significant (adjusted p values = 0.091). The IVW, MR-Egger analysis, and weighted median methods showed no causal association between coffee consumption and SLE risk (beta = 0.594, SE = 0.437, p = 0.209; beta = 3.100, SE = 3.632, p = 0.550; beta = 0.733, SE = 0.567, p = 0.196). MR analysis results do not support causal associations between coffee consumption and the development of RA and SLE. | en_US |
dc.description.sponsorship | This study was supported in part by a grant from the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPRINGER LONDON LTD | en_US |
dc.subject | Coffee | en_US |
dc.subject | Mendelian randomization | en_US |
dc.subject | RA | en_US |
dc.subject | SLE | en_US |
dc.title | Coffee consumption and the risk of rheumatoid arthritis and systemic lupus erythematosus: a Mendelian randomization study | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 37 | - |
dc.identifier.doi | 10.1007/s10067-018-4278-9 | - |
dc.relation.page | 2875-2879 | - |
dc.relation.journal | CLINICAL RHEUMATOLOGY | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.relation.code | 2018008146 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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