Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2019-12-09T19:00:55Z | - |
dc.date.available | 2019-12-09T19:00:55Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | LUPUS, v. 27, no. 11, page. 1854-1859 | en_US |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.issn | 1477-0962 | - |
dc.identifier.uri | https://journals.sagepub.com/doi/10.1177/0961203318794871 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120380 | - |
dc.description.abstract | Mesenchymal stem cell therapy is a promising candidate for the treatment of systemic lupus erythematosus (SLE). To exert their efficacy fully, mesenchymal stem cells must infiltrate efficiently into the lesion sites. Here, we examined the role of CXCR3 in mesenchymal stem cell infiltration into the kidney of MRL.Fas(lpr) mice, which highly expressed CXCL10. The phenotypes, production of immunosuppressive mediators, and capacity to inhibit T and B cells of CXCR3-deficient mesenchymal stem cells were similar to those of wild-type mesenchymal stem cells. However, they showed less infiltration into the nephritic kidney, less conjugation with endothelial cells and weaker MMP-9 expression than did wild-type mesenchymal stem cells. Consequently, CXCR3-deficient mesenchymal stem cells did not ameliorate lupus symptoms in MRL.Fas(lpr) mice in comparison with wild-type mesenchymal stem cells. In summary, our data suggest that upregulation of CXCR3 in mesenchymal stem cells will be a good strategy to increase their infiltration into the kidney, which will improve therapeutic outcomes in SLE. | en_US |
dc.description.sponsorship | The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: this work was supported by grants funded by the Korean government (NRF-2017R1A5A2015541 and NRF-2017M 3A9B4050336). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SAGE PUBLICATIONS LTD | en_US |
dc.subject | Systemic lupus erythematosus | en_US |
dc.subject | mesenchymal stem cell | en_US |
dc.subject | CXCR3 | en_US |
dc.subject | kidney infiltration | en_US |
dc.title | CXCR3-deficient mesenchymal stem cells fail to infiltrate into the nephritic kidney and do not ameliorate lupus symptoms in MRL.Fas(lpr) mice | en_US |
dc.type | Article | en_US |
dc.relation.no | 11 | - |
dc.relation.volume | 27 | - |
dc.identifier.doi | 10.1177/0961203318794871 | - |
dc.relation.page | 1854-1859 | - |
dc.relation.journal | LUPUS | - |
dc.contributor.googleauthor | Lee, J. H. | - |
dc.contributor.googleauthor | Lee, H. K. | - |
dc.contributor.googleauthor | Kim, H. S. | - |
dc.contributor.googleauthor | Kim, J. S. | - |
dc.contributor.googleauthor | Ji, A. Y. | - |
dc.contributor.googleauthor | Lee, J. S. | - |
dc.contributor.googleauthor | Kim, K. S. | - |
dc.contributor.googleauthor | Lee, T. Y. | - |
dc.contributor.googleauthor | Bae, S. C. | - |
dc.contributor.googleauthor | Kim, Y. | - |
dc.relation.code | 2018003705 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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