Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김봉영 | - |
dc.date.accessioned | 2019-12-09T18:45:50Z | - |
dc.date.available | 2019-12-09T18:45:50Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 8, Article no. 14757 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/s41598-018-33201-8 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120362 | - |
dc.description.abstract | The aim of this study was to evaluate the impact of an infectious diseases specialist (IDS)-led antimicrobial stewardship programmes (ASPs) in a large Korean hospital. An interrupted time series analysis assessing the trends in antibiotic use and antimicrobial resistance rate of major pathogens between September 2015 and August 2017 was performed in an 859-bed university-affiliated hospital in Korea. The restrictive measure for designated antibiotics led by an IDS reduced carbapenems usage by -4.57 days of therapy (DOT)/1,000 patient-days per month in general wards (GWs) (95% confidence interval [CI], -6.69 to -2.46; P < 0.001), and by -41.50 DOT/1,000 patient-days per month in intensive care units (ICUs) (95% CI, -57.91 to -25.10; P < 0.001). Similarly, glycopeptides usage decreased by -2.61 DOT/1,000 patient-days per month in GWs (95% CI, -4.43 to -0.79; P = 0.007), and -27.41 DOT/1,000 patient-days per month in ICUs (95% CI, -47.03 to -7.79; P = 0.009). Use of 3rd generation cephalosporins, beta-lactam/beta-lactamase inhibitors, and fluoroquinolones in GWs showed change comparable with that of carbapenems or glycopeptides use. Furthermore, trends of antimicrobial resistance rate of Staphylococcus aureus to gentamicin in GWs, Staphylococcus aureus to ciprofloxacin and oxacillin in ICUs, and Pseudomonas aeruginosa to imipenem in ICUs decreased in slope in the intervention period. The in-hospital mortality rate per 1,000 patient-days among ICU patients remained stable between the pre-intervention and intervention periods. In conclusion, an IDS-led ASPs could enact a meaningful reduction in antibiotic use, and a decrease in antibiotic resistance rate, without changing mortality rates in a large Korean hospital. | en_US |
dc.description.sponsorship | This study was supported by the research fund of Hanyang University (HY-2018). The authors thank all medical staff in Eulji University Hospital for their cooperation in the antimicrobial stewardship programmes. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | INTERRUPTED TIME-SERIES | en_US |
dc.subject | RESTRICTION | en_US |
dc.subject | SOCIETY | en_US |
dc.title | Impact of an infectious diseases specialist-led antimicrobial stewardship programmes on antibiotic use and antimicrobial resistance in a large Korean hospital | en_US |
dc.type | Article | en_US |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.1038/s41598-018-33201-8 | - |
dc.relation.page | 1-10 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Hwang, Hyeonjun | - |
dc.contributor.googleauthor | Kim, Bongyoung | - |
dc.relation.code | 2018003596 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sobakas | - |
dc.identifier.researcherID | H-3409-2018 | - |
dc.identifier.orcid | http://orcid.org/0000-0002-5029-6597 | - |
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