Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상경 | - |
dc.date.accessioned | 2019-12-09T18:19:54Z | - |
dc.date.available | 2019-12-09T18:19:54Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 8, Article no. 15041 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/s41598-018-33296-z | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120338 | - |
dc.description.abstract | Ischemic stroke-induced neuronal cell death results in the permanent disabling of brain function. Apoptotic mechanisms are thought to play a prominent role in neuronal injury and ample evidence implicates Fas signaling in mediating cell death. In this study, we describe the neuroprotective effects of a Fas-blocking peptide (FBP) that by obstructing Fas signaling in cerebral ischemia inhibits apoptosis. Using an intranasal administration route in a rat model of focal cerebral ischemia, we demonstrate that nose-to-brain delivery of FBP after middle cerebral artery occlusion (MCAO) surgery results in the delivery and retention of FBP in Fas-expressing ischemic areas of the brain. A single intranasal administration of 2 mg/kg FBP resulted in significantly reduced neuronal cell death by inhibiting Fas-mediated apoptosis leading to decreased infarct volumes, reduced neurologic deficit scores and recovery from cerebral ischemia. Intranasally delivered FBP might be a promising strategy for the treatment of cerebral ischemic stroke. | en_US |
dc.description.sponsorship | This work was supported by NIH grant R01AI112443 to P.K. and the Korea National Research. Foundation grant 2017R1D1A1B03029636 and 2018R1D1A1B07050464 to S.K.L. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | NASAL DRUG-DELIVERY | en_US |
dc.subject | GLUCOSE-TRANSPORTER | en_US |
dc.subject | STROKE | en_US |
dc.subject | MECHANISMS | en_US |
dc.subject | BARRIER | en_US |
dc.subject | TARGET | en_US |
dc.subject | SIRNA | en_US |
dc.subject | CELL | en_US |
dc.subject | MEMBRANES | en_US |
dc.subject | NECROSIS | en_US |
dc.title | Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.1038/s41598-018-33296-z | - |
dc.relation.page | 1-10 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Ullah, Irfan | - |
dc.contributor.googleauthor | Chung, Kunho | - |
dc.contributor.googleauthor | Oh, Jungju | - |
dc.contributor.googleauthor | Beloor, Jagadish | - |
dc.contributor.googleauthor | Bae, Sumin | - |
dc.contributor.googleauthor | Lee, Sangah Clara | - |
dc.contributor.googleauthor | Lee, Minhyung | - |
dc.contributor.googleauthor | Kumar, Priti | - |
dc.contributor.googleauthor | Lee, Sang-Kyung | - |
dc.relation.code | 2018003596 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | sangkyunglee | - |
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