Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김태형 | - |
dc.date.accessioned | 2019-12-09T17:32:38Z | - |
dc.date.available | 2019-12-09T17:32:38Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | TUBERCULOSIS AND RESPIRATORY DISEASES, v. 81, no. 4, page. 289-298 | en_US |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.issn | 2005-6184 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4046/trd.2017.0064 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120300 | - |
dc.description.abstract | Background: Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS.Methods: A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers.Results: Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year.Conclusion: Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | TAEHAN KYORHAEK HYOPHOE-KOREAN ACAD TUBERCULOSIS & RESPIRATORY DISEASES | en_US |
dc.subject | Asthma | en_US |
dc.subject | Pulmonary Disease | en_US |
dc.subject | Chronic Obstructive | en_US |
dc.subject | Phenotype | en_US |
dc.title | Increased risk of exacerbation in asthma predominant asthma-chronic obstructive pulmonary disease overlap syndrome | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 81 | - |
dc.identifier.doi | 10.4046/trd.2017.0064 | - |
dc.relation.page | 289-298 | - |
dc.relation.journal | Tuberculosis and Respiratory Diseases | - |
dc.contributor.googleauthor | Park, Jisoo | - |
dc.contributor.googleauthor | Kim, Eun-Kyung | - |
dc.contributor.googleauthor | Kim, Mi-Ae | - |
dc.contributor.googleauthor | Kim, Tae-Hyung | - |
dc.contributor.googleauthor | Chang, Jung Hyun | - |
dc.contributor.googleauthor | Ryu, Yon Ju | - |
dc.contributor.googleauthor | Lee, Sei Won | - |
dc.contributor.googleauthor | Oh, Yeon-Mok | - |
dc.contributor.googleauthor | Yong, Suk Joong | - |
dc.contributor.googleauthor | Choi, Won-Il | - |
dc.relation.code | 2018042818 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | drterry | - |
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